Purpose of this Study
We are doing this study to learn more about how different factors affect people with two types of dry eye conditions: Sjögren's dry eye (SjD) and non-Sjögren's dry eye. Specifically, we want to know how neurotrophic keratitis (a condition where the cornea loses sensation) versus the severity of tear film and eye surface issues impact the structure and function of the cornea (the clear front part of the eye). We also want to find out if having dry eyes leads to less feeling in the cornea, and if this reduced feeling is linked to eye pain or pain in other parts of the body.
Who Can Participate?
Eligibility
Adults ages 18+ who:
- Are diagnosed with dry eye
- Are diagnosed with Sjögren's Syndrome
- Have no history of glaucoma surgery
Age Range
18-110
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No
What is Involved?
Description
If you choose to join this study, you will come in for a single visit to have the following procedures:
- An eye exam
- Imaging scans of the eye
- Questionnaires
Locations
Duke University Hospital
Visit Timing
Weekdays
Compensation
No
Spanish Materials Available
No
Study Details
Full Title
Role of Neurotrophic Keratitis versus Severity of Tear Film and Ocular Surface Parameters in Determining the Differences in Corneal Structure and Function in Patients with Sjögren's vs. non-Sjögren's Dry Eye - IIR-2023-1274
Principal Investigator
Amol
Sura
Protocol Number
PRO00117774
Phase
N/A
Enrollment Status
Pending Open to Enrollment