Clinical Trials Directory

442 clinical trials found.
Brain, Spinal Cord and Nerves

We are doing this study to look at components of the blood to see if there are features that distinguish people with dystonia from people without dystonia. Identifying "biomarkers" in the blood that are associated with dystonia is greatly needed to help more accurately diagnosis dystonia and to identify subsets of dystonias that may have shared mechanisms. Being able to group individuals by underlying mechanisms can guide people with dystonia to the most appropriate future treatments that act specifically to correct one cause or another.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital
Gastrointestinal Cancer

We are doing this study to compare the usual treatment (surgery plus chemotherapy afterward) to using chemotherapy both before and after surgery.

Compensation: No
Oncology
Gastrointestinal Cancer

We are doing this study to find out if infusing chemotherapy drugs directly into the hepatic artery (the blood vessel that supplies blood to the liver) is a better treatment option than standard chemotherapy for people who have colorectal cancer that has spread to the liver.

Compensation: No
Oncology
Skin Cancer - Melanoma

We are doing this study to compare the safety and effects of stopping the standard melanoma treatments of nivolumab + pembrolizumab or nivolumab + relatlimab at different times. We hope this study will help us discover certain markers from imaging and biopsies that can signal when it is the appropriate time to stop therapy.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Sarcoma

We are doing this study to compare the usual treatments of surgery alone to using chemotherapy before surgery. We want to know if adding doxorubicin and ifosfamide chemotherapy for liposarcoma (LPS) or doxorubicin and dacarbazine chemotherapy for leiomyosarcoma (LMS) before surgery can improve the long-term survival for patients with these cancers.

Compensation: No
Oncology
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an experimental combination of drugs is an effective treatment for ALL. The combination used in the study is blinatumomab (the study drug) + steroids and tyrosine kinase inhibitors (TKI). We want to know if this drug combination is more effective than the standard treatment of chemotherapy + steroids and TKI.

Compensation: No
Ages: 18-75
Oncology
Duke University Hospital
Brain and Spine Metastasis

We are doing this study to find out how different imaging techniques can help with the evaluation of glioblastoma.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Kidneys, Bladder and Urinary System

We are doing this study to be an early access program to treat C3G or IC-MPGN, which may lead to damage in your kidneys, protein in your urine, high blood pressure, and swelling of your hands, feet, and ankles.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital