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The COMET Study includes up to 4 visits to the study center. Each visit lasts about 2 to 3 hours. During the visits, children will wear special equipment for a brain test called an EEG and do fun, play-based activities. Parents or caregivers may be asked to answer questions or do interviews at home. Families will get $50 for each visit.

We are doing this study to compare measures of brain function after surgical circulatory arrest ( when the surgeon stops the heart-lung machine to work on your heart) in antegrade perfusion versus retrograde perfusion. Antegrade and retrograde perfusion are 2 different ways to supply blood to the brain during this type of surgery. In antegrade perfusion, the surgeon accesses one of two arteries that branch off from the aorta (the artery that delivers blood to the rest of the body) to provide blood to the brain. In retrograde perfusion, the surgeon accesses the superior vena cava (large vein bringing blood back to the heart) to supply blood to the brain. Both methods are commonly used, but we want to find out if one method works better for most people than the other.

This study lasts about three months. People will first have two screening visits to see if they can join. They will then receive five days of treatment in a row. After treatment, they will return for follow up visits about one week, one month, and three months later. Participants will be placed into one of two groups by chance and will receive different doses of a treatment called transcranial magnetic stimulation. This treatment uses magnets placed outside the head and does not require surgery. During the study, participants will answer questions about their pain and daily life, have a brain MRI scan, and complete tests that measure sensation and brain function. The goal is to learn if this treatment can help reduce long lasting pain after a stroke.

People who join this study will take one study pill every day until they are 36 weeks pregnant. They will also have monthly visits with the study team, either in person or virtually, until their baby is born. Researchers will collect health information about both the mother and baby through the time they leave the hospital after delivery. The goal is to learn if the study treatment can help lower the chance of another early birth.

We are doing this study to learn more about Alzheimer's disease and other illnesses of aging (e.g., dementia, mild cognitive impairment [MCI], or other cognition disorders).

We are doing this study to learn more about sleep and body rhythms in children with ADHD. We will use home-based measures, parent reports, and an evening test to see how sleep affects mental health and thinking skills. Dr. Jessica Lunsford-Avery from the Department of Psychiatry is leading this study.

We are doing this study to find out if carefully watching patients with low risk germ cell tumors after surgery will have different results than treating people with chemotherapy afer their surgery. For people who are in standard risk groups related to germ cell tumors, we want to compare the effects of carboplatin with cisplatin and find out which of these drugs seems to work better.