ALADDIN (Aging and Memory Study)

Purpose of this Study

We are doing this study to help us identify the underlying causes of brain disorders such as delirium and/or dementia.

Who Can Participate?

Eligibility

Adults ages 65+ who:
- Are scheduled to have surgery in the next few months
- Are able to speak English
- Are able to give consent

For more information about the study, please contact the study team at noah.timko@duke.edu.

What is Involved?

If you choose to join this study, you will:
- Undergo memory and thinking tests and complete surveys prior to surgery and again 3 months and 1 year after surgery
- Have a blood draw before surgery and again at 3 months and 1 year after surgery
- Have a lumbar puncture (spinal tap) and an MRI/fMRI scan before surgery
- Have your brain activity recorded during surgery through a technique called EEG, which measures brain waves through a thin cap that you wear on your head

To learn more about the study, please watch this video: https://www.youtube.com/watch?v=nLAXWzdeWIk

What is it like to undergo a lumbar puncture (spinal tap) with the Duke Anesthesiology study team? Watch these two videos of Dr. Berger discussing the procedure with two past study participants:

Video 1: https://www.youtube.com/watch?v=XnMbUKPSDZI
Video 2: https://www.youtube.com/watch?v=XtOvEW3WCYM

Study Details

Full Title

Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and Inattention

Principal Investigator

Miles
Berger

Protocol Number

PRO00110914

Phase

N/A

Enrollment Status

OPEN TO ACCRUAL