Purpose of this Study
We are doing this study to help us identify the underlying causes of brain disorders such as delirium and/or dementia.
Who Can Participate?
Eligibility
Adults ages 65+ who:
- Are scheduled to have surgery in the next few months
- Are able to speak English
- Are able to give consent
For more information about the study, please contact the study team at noah.timko@duke.edu.
- Are scheduled to have surgery in the next few months
- Are able to speak English
- Are able to give consent
For more information about the study, please contact the study team at noah.timko@duke.edu.
What is Involved?
If you choose to join this study, you will:
- Undergo memory and thinking tests and complete surveys prior to surgery and again 3 months and 1 year after surgery
- Have a blood draw before surgery and again at 3 months and 1 year after surgery
- Have a lumbar puncture (spinal tap) and an MRI/fMRI scan before surgery
- Have your brain activity recorded during surgery through a technique called EEG, which measures brain waves through a thin cap that you wear on your head
To learn more about the study, please watch this video: https://www.youtube.com/watch?v=nLAXWzdeWIk
What is it like to undergo a lumbar puncture (spinal tap) with the Duke Anesthesiology study team? Watch these two videos of Dr. Berger discussing the procedure with two past study participants:
Video 1: https://www.youtube.com/watch?v=XnMbUKPSDZI
Video 2: https://www.youtube.com/watch?v=XtOvEW3WCYM
- Undergo memory and thinking tests and complete surveys prior to surgery and again 3 months and 1 year after surgery
- Have a blood draw before surgery and again at 3 months and 1 year after surgery
- Have a lumbar puncture (spinal tap) and an MRI/fMRI scan before surgery
- Have your brain activity recorded during surgery through a technique called EEG, which measures brain waves through a thin cap that you wear on your head
To learn more about the study, please watch this video: https://www.youtube.com/watch?v=nLAXWzdeWIk
What is it like to undergo a lumbar puncture (spinal tap) with the Duke Anesthesiology study team? Watch these two videos of Dr. Berger discussing the procedure with two past study participants:
Video 1: https://www.youtube.com/watch?v=XnMbUKPSDZI
Video 2: https://www.youtube.com/watch?v=XtOvEW3WCYM
Study Details
Full Title
Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and Inattention
Principal Investigator
Miles
Berger
Protocol Number
PRO00110914
Phase
N/A
Enrollment Status
OPEN TO ACCRUAL