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404 clinical trials found.
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an investigational drug called fostamatinib (the study drug) is beneficial for cGvHD when it is used in combination with a standard of care drug, ruxolitinib. We want to know if the study drug can improve relief from cGvHD symptoms.

Compensation: No
Oncology
Eyes and Vision

We are doing this study to find out if an investigational drug called tinlarebant (the study drug) is safe and useful for treating geographic atrophy (GA).

Compensation: Yes
Ages: 60-85
Non-Oncology
Duke University Hospital
Breast Cancer

We are doing this study to find out how an experimental vaccine (pING-hHER3FL) works in your body and against your cancer.

Compensation: No
Oncology
Breast Cancer

We are doing this study to find out if the combination of two hormonal drugs, giredestrant and fulvestrant, are a safe and effective option if they are given with the study doctor's choice of a class of medicines called CDK4/6 inhibitors to people who have ER-positive, HER2-negative breast cancer that is resistant to standard treatments.

Compensation: No
Oncology
Bones, Joints and Muscles

We are doing this study to find out what factors affect how well platelet rich plasma (PRP) injections work for people who choose to get them to treat a problem with their hip, knee, or shoulder joint. We hope the information we get from this study will help us find out what effects, if any, factors like age, gender, medical conditions, or injury history have on the outcomes of these injections.

Compensation: No
Ages: 18-110
Non-Oncology
Other
Pediatric Cancer

We are doing this study to find out if the combination of an experimental drug called ONC201 (the study drug) with paxalisib is an effective option for patients with a diffuse midline glioma (DMG). We also want to see how much of these drugs are absorbed by tumor tissue in patients with brain tumors.

Compensation: No
Ages: 2-29
Oncology
Duke University Hospital
Eyes and Vision

We are doing this study to gather information on Stargardt Disease Type 1 (STGD1) and how it develops over time.

Compensation: Yes
Ages: 12-65
Non-Oncology
Duke University Hospital
Sarcoma

We are doing this study to find out if an experimental drug called ADI-PEG 20 (the study drug) combined with two types of FDA-approved chemotherapies (gemcitabine and docetaxel) is a safe and effective option for people who have leiomyosarcoma.

Compensation: No
Oncology