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People who have shoulder surgery are given medicine so they do not feel pain during the procedure. This includes a nerve block that makes the shoulder numb, along with medicine that keeps the person asleep. The nerve block usually keeps the shoulder numb for about three to five days. Pain after surgery often lasts longer than this. In this study, doctors are testing whether adding another medicine called dexamethasone can make the numbness last longer. If you join the study, you will be placed into one of two groups. One group will get the usual nerve block, and the other group will get the nerve block with the extra medicine. In both groups, you will be asleep during surgery. The only difference is how long the numbness in the shoulder may last.

30-45 min interview (in person or over zoom) and a brief survey

We are doing this study to evaluate an experimental technology called the Reprieve Decongestion Management System (the study device) for heart failure patients with fluid overload. The study device is designed to help people with heart failure feel better by removing extra fluid from their body quickly. The device is programmed to deliver an appropriate amount of medication at the right time to help people shed extra fluid through urination. We want to know if this device works better than the standard treatment. The standard treatment is to prescribe diuretics (medication to increase urination) at a specified dose and dosage schedule.

We are doing this study to examine genetic changes in your tumor that may contribute to resistance to immunotherapy. With this information, we hope to be able to identify new treatment methods as well as improve our ability to identify patients more likely to respond to immunotherapy.

After the screening, the study will last up to one year and has two parts. People in the study will be randomly placed into two groups. In Part A, one group will get the study medicine, and the other group will get a placebo, which looks like the medicine but does not do anything. In Part B, everyone will get the study medicine. The medicine or placebo will be given through a tube into a vein in the arm. During the study, everyone will have checkups, give blood samples, have kidney tissue samples taken (called biopsies), and answer questions about how they feel.

We are doing this study to find the most effective, safe dose of an experimental drug called FG-3246 (the study drug) that is being developed for people with metastatic castration-resistant prostate cancer. We want to know if it is able to shrink the size of tumors and delay the progression of the disease.