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435 clinical trials found.
Heart and Circulation

We are doing this study to learn more about ATTR and its different variants and how they can can be better diagnosed, managed, and treated.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Heart and Circulation

We are doing this study to find out if an experimental drug called NTLA-2001 (the study drug) is a safe and effective option for people with transthyretin amyloidosis with cardiomyopathy (ATTR-CM). The study drug is made using the CRISPR-CaS9 gene editing system. The intent of the study drug that is being tested is to target the TTR gene and make it inactive.

Compensation: Yes
Ages: 18-90
Non-Oncology
Duke University Hospital
Heart and Circulation

We are doing this study to learn more about heart valve disease and its standard-of-care treatments, and we want to learn more about the safety and performance of the Corcym devices and accessories used for heart valve disease.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an experimental CAR-T cell therapy called MB-CART2019.1 (the study drug) may help eliminate cancer cells in patients who have relapsed or refractory DLBCL. The study drug will be combined with fludarabine and cyclophosphamide, which are both standard drugs used to treat DLBCL.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Heart and Circulation

We are doing this study to learn more about the safety and performance of heart valve repair and replacement products made by Medtronic.

Compensation: No
Non-Oncology
Kidneys, Bladder and Urinary System

We are doing this study to keep tabs on the health status of people who have used, or who plan to use, a Medtronic® medical device to treat a urological or digestive disorder. This study is a registry, which means that it will allow us to compile information about how well these products work and how well they improve patients' quality of life.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital, Duke Raleigh Hospital, Other
Skin Cancer - Melanoma

We are doing this study to look at blood, tumor, and lymph node tissue from people with melanoma so we can improve diagnostic methods and therapies for people with melanoma.

Compensation: No
Oncology
Women's Health

We are doing this study to learn more about the symptoms of menopause in women with sickle cell disease (SCD). We want to learn more about how hydroxyurea, pain, and other SCD-related complications can affect their menopause experience. We hope this study can help us more quickly and easily find out when women with SCD might be experiencing health complications related to menopause.

Compensation: No
Ages: 35-110
Non-Oncology
Remote/online