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In this study, people may be placed into one of two groups when they join. One group will receive chemotherapy that lowers the immune system before getting the study treatment, and the other group will not. Everyone in the study will receive special CAR T cells that are made to fight disease. After receiving the cells, participants will stay in the hospital for several days so doctors can watch their health closely. They must also stay near the study center for about 45 days and will have regular doctor visits during that time.

In this study, participants will first receive chemotherapy for one to three days to lower their immune system. After that, they will receive special CAR T cells in the hospital and stay there so doctors can watch them closely. For the first month after receiving the cells, participants will be monitored very carefully and must stay near the study center for about 30 days. After that, they will return to the clinic once a month for at least two years so doctors can continue to check their health.

People in this study will be placed into one of two groups by chance, like flipping a coin. One group will get two medicines called DSP107 and Atezolizumab together. The other group will get a medicine called Fruquintinib by itself. Each treatment cycle lasts 4 weeks and can continue for up to 2 years. Doctors will check health and safety during the study. After the last dose, there will be a follow-up period of up to 90 days.

We have created this repository as a way for people to let us know they are interested in being contacted about future research studies. These studies will aim to improve the health and wellbeing of people by using mobile technology or other interventions. If you would like more information please contact us at dbhtl@duke.edu

Our Duke Vaccine and Trials Unit Volunteer Registry is a way for people to let our team know that you are interested in learning more about any of our vaccine studies. For more information or to sign up, visit us at: https://redcap.duke.edu/redcap/surveys/?s=WPL7XPK4JYHY4NYK

Our Duke Health and Exercise Research Trials Registry is a way for people to let our team know that they are interested in learning more about any of our studies for which they may qualify. Our studies include both healthy people and those who may have certain medical conditions.