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439 clinical trials found.
Gastrointestinal Cancer

We are doing this study to find out if giving the drugs floxuridine and oxaliplatin directly into the hepatic artery of the liver is a safe and effective option for patients with localized pancreatic ductal adenocarcinoma. This form of drug delivery will be combined with surgery and standard chemotherapy in this study. Chemotherapy can happen either before or after the delivery of drugs directly into the hepatic artery. We also want to see how this regimen works to improve the rate of liver metastasis (cancer that has spread to the liver) after surgery.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Blood Disorders

We are doing this study to find out if an experimental drug called etavopivat (the study drug) is a safe and effective option for children and adolescents who have SCD.

Compensation: Yes
Ages: 12-17
Non-Oncology
Other
Immune System and Infections

Many people with HIV want to breastfeed their babies, but until recently, the rules in the U.S. didn't allow this. There's a small risk of passing HIV to the baby, but we need more information to understand this better. This research will make a list of babies and how they are fed, talk to families about why they choose certain ways to feed their babies, and test breast milk and blood to see if the HIV that can't be found in the blood is also not in the breast milk.

Compensation: Yes
Ages: 18-50
Non-Oncology
Duke University Hospital, Other
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an experimental drug called abatacept (the study drug) is a safe and effective option to help prevent graft-versus-host (GVHD) disease for people who get an omidubicel hematopoietic stem cell transplant to treat blood cancer. Omidubicel is a recently approved (2023) stem cell transplantation that uses modified umbilical cord blood. This new method of stem cell transplantation helps patients' immune systems recover more quickly after intensive chemotherapy.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Brain, Spinal Cord and Nerves

We are doing this study to learn if hyperbaric oxygen therapy is helpful to people with traumatic brain injury.

Compensation: No
Ages: 16-65
Non-Oncology
Duke University Hospital
Research for Healthy Adults

If you agree to be in the study, you will have 1 study visit that will last about 4 hours. The visit will include asking questions about your medical history, vital signs, pulmonary function tests (PFTs) and an MRI (magnetic resonance image) of the chest with inhaled Xenon gas. Someone from the study team will contact you about 24 hours after your study visit.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Immunology and Rheumatology

We are doing this study to find out if an experimental drug called dazodalibep (the study drug) can improve symptoms for people who have Sjogren's Syndrome.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Breast Cancer

We are doing this study to analyze biomarker responses to different drug regimens used for people who have HER2- and HER2+ breast cancer. We hope what we learn from the study can help us develop better treatments and figure out which treatment option(s) will be best for breast cancer patients.

Compensation: No
Ages: 18-90
Oncology
Duke University Hospital, Duke Raleigh Hospital