Clinical Trials Directory

This is an observational study and will only be a one-time saliva sample and a completion of a questionnaire.

If you join this study, you will be placed into one of two groups by chance, like flipping a coin. One group will take a medicine called velzatinib, and the other group will take a medicine called imatinib. You will take the medicine by mouth every day. The study has three parts called screening, treatment, and follow up. During screening, doctors will do tests to make sure the study is right for you. During treatment, you will visit the clinic about once every four weeks for checkups, blood tests, and scans. You may stay in the study for a long time if the medicine is helping and is safe, with participation lasting up to about six years. After you stop taking the medicine, the study team will continue to check on your health through visits or phone calls.

If you take part in this study, you will take a study supplement or placebo for 12 weeks and attend study visits that include breathing tests, lung function tests, strength and walking tests, exercise testing, blood draws, and questionnaires about your physical activity and diet.

In this study, people will answer questions and do simple physical tests three times over six months. They will be randomly placed into one of two groups: one gets coping skills training with a nurse by phone, and the other gets regular care. Everyone will also get a short health check during cancer visits to look for problems like memory loss or falling.

We are doing this study to find out if giving heated chemotherapy into the belly, a procedure known as heated intraperitoneal chemotherapy (HIPEC), can improve treatment results for patients with ovarian cancer.

We are doing this study to find the most effective, safe dose of an experimental drug called raludotatug deruxtecan (the study drug) and to see if your disease or medical condition improves while taking it.