Clinical Trials Directory

434 clinical trials found.
Head and Neck Cancer

We are doing this study to find out if an experimental drug called cemiplimab (the study drug) is a safe and effective option for people who have untreated cutaneous squamous cell carcinoma (CSCC). We want to know if the study drug can help shrink this cancer and prevent it from returning after it is treated with surgery.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Radiation Oncology

We are doing this study to find out if stereotactic body radiation therapy (SBRT) might be beneficial for people with non-small cell lung cancer (NSCLC). We want to compare the outcomes between the standard treatment for NSCLC and the standard treatment with the addition of SBRT.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital, Other
Eyes and Vision

We are doing this study to find out if an experimental drug called NT-101 (the study drug) is a safe and effective option for people with wet age-related macular degeneration (AMD). The study drug is a topical solution that is administered directly to the eye (eye drops).

Compensation: Yes
Ages: 50-110
Non-Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called NX-5948 (the study drug). We want to know how well this study drug works in people with B-cell lymphomas.

Compensation: No
Oncology
Trauma and Emergency Department Studies

We are doing this study to find out if an experimental drug called DefenCath® (the study drug) is a safe and effective means to lower the risk of central line infections for people who need total parenteral nutrition (TPN). TPN is when people get their necessary nutrients through a catheter in a vein because they are unable to properly digest food for nutrition. We want to know how well the study drug works compared to heparin catheter lock solution, which is the current option to help prevent infections.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital, Pickett Road Research
Thoracic Cancer

We are doing this study to find the most effective, safe dose of an experimental drug called NVL-655 (the study drug). We want to know how well the study drug works compared to alectinib, which is a standard treatment for NSCLC.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Bones, Joints and Muscles

We are doing this study to find out which type of surgery has the best outcomes for people who have shoulder dislocations with bone loss. There are 3 types of surgeries that doctors can perform to stabilize the shoulder of people who have this type of injury, but there is no evidence at this time that proves one is better than the others. We hope this study can help us figure out how to choose the best option for different patients. This is an observational study and participation will not affect the treatment option you choose to pursue.

Compensation: Yes
Ages: 18-50
Non-Oncology
Other
Eyes and Vision

We are doing this study to find out if an experimental gene transfer drug called OCU410ST is a safe and effective option for Stargardt Disease (STGD).

Compensation: Yes
Ages: 6-75
Non-Oncology
Duke University Hospital