Clinical Trials Directory

We are doing this study to find out if using ice with or without compression during chemotherapy can prevent neuropathy for patients being treated for gynecologic cancer.

We are doing this study to collect cerebrospinal fluid (CSF) samples from people with cancer that has spread to the leptomeninges (the inner membranes that cover the brain and spinal cord). These CSF samples will be used in laboratory research projects to identify substances called biomarkers. Biomarker testing is a way to look for genes, proteins, and other substances (tumor markers) that can provide information about cancer. Information from these CSF samples may help us learn about new methods to treat metastatic disease to the leptomeninges.

In this study, people will take capsules that contain either the study drug, called vamifeport, or a placebo, which looks the same but has no medicine. The study lasts about fourteen months and has around fifteen in person visits. At these visits, people will have blood tests, heart tests called ECGs, MRI scans, and questionnaires. If someone gets vamifeport, they will take it twice a day in one of two dose groups. One group takes 90 milligrams twice a day, which is one capsule in the morning and one in the evening. The other group takes 270 milligrams twice a day, which is three capsules in the morning and three in the evening. If someone gets a placebo, they will also take either one capsule twice a day or three capsules twice a day, depending on their group.

We are doing this study to find out if an investigational drug called tocilizumab (the study drug) will lead to better outcomes after lung transplantation when it is combined with standard anti-rejection medicines.

We are doing this research to learn more about whether taking a blood thinner, along with medications that prevent blood clots, improve outcomes in patients who develop atrial fibrillation (irregular heartbeat) after coronary artery bypass grafting surgery.

Participants will receive the study drug in one eye during an outpatient surgery and will not need to stay in the hospital. Participation will last about 5 years and 5 months and includes 17 study visits, 1 phone visit, and regular tests and eye examinations.