Clinical Trials Directory

549 clinical trials found.
Lungs and Breathing

We are doing this study to find out if an investigational drug called tocilizumab (the study drug) will lead to better outcomes after lung transplantation when it is combined with standard anti-rejection medicines.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital
Heart and Circulation

We are doing this research to learn more about whether taking a blood thinner, along with medications that prevent blood clots, improve outcomes in patients who develop atrial fibrillation (irregular heartbeat) after coronary artery bypass grafting surgery.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital, Duke Regional Hospital
Eyes and Vision

At various visits, you will have blood tests, eye exams, and vision tests.

Compensation: Yes
Ages: 55-110
Non-Oncology
Duke University Hospital
Primary Brain and Spinal Cord Tumors

We are doing this study to find out if an investigational drug called CA-4948 is a safe and effective option for people with PCNSL. We want to know how well it works when it is combined with a drug called ibrutinib, which is commonly used to treat PCNSL.

Compensation: Yes
Ages: 18-110
Oncology
Duke University Hospital

This study is testing a new way to guide a brain stimulation tool called TMS by using a camera to track a person's head. The goal is to do this without needing special headgear. Researchers hope this new method will make the treatment more comfortable and easier for people. They also want to see if it helps aim the tool more accurately, which could improve how well the treatment works.

Compensation: Yes
Ages: 18-110
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an experimental drug called CT01681 (the study drug) is a safe and effective option for people who get CAR T-cell therapy as a treatment for diffuse large B cell lymphoma (DLBCL). We want to know if the study drug has the potential to lower or prevent certain side effects of CAR T-cell therapy. The possible side effects of CAR T-cell therapy that the study drug is being developed to protect against are called cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome. This study is enrolling people who will receive an available form of CAR T-cell therapy called YESCARTA.

Compensation: No
Oncology
Primary Brain and Spinal Cord Tumors

We are doing this study to see if an experimental combination of drugs (D2C7-IT and 2141-V11) is a safe treatment for brain tumors.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital