Clinical Trials Directory
Participants will be admitted to the Duke Early Phase Unit for 2 nights, and receive an infusion of either the study drug or placebo. Safety will be monitored for at least 24 hours after the infusion, and there will be numerous blood draws.
People in this study will keep taking their regular HIV medicines. They will receive either a study medicine called GS 0415 or a placebo, which has no active medicine. The study medicine may be given as a shot under the skin or through a vein. During the study, participants will have clinic visits for physical exams, blood and urine tests, heart tests, and HIV testing. Depending on the study group, they may receive one dose or up to five doses of the study medicine. Some visits will include staying overnight in the clinic so doctors can watch for side effects and make sure the treatment is safe. The study lasts about three months and is designed to learn more about the safety and effects of GS 0415 in people living with HIV.
This study starts with a screening visit to see if a person can join. After that, there are thirteen study visits over about twenty weeks. During this time, participants will receive three shots of the study medicine called DISC 3045 given under the skin. All study visits include blood tests, and one visit will include two blood draws. People may also choose to stay in the study longer for another twelve weeks. If they continue, they will receive three more shots of the study medicine and have seven more study visits with blood tests.
In this study, people will be placed into one of two groups by chance, like flipping a coin. One group will receive a medicine called nipocalimab, and the other group will receive a placebo, which looks the same but has no medicine. The medicine is given through a vein every two weeks for about 24 weeks. During the study, participants will have clinic visits, blood tests, exams, and answer questions about how they feel. After this part is finished, some people may have the option to continue in another part of the study and receive the study medicine.
In this study, people will be placed into one of two groups by chance. One group will receive the study medicine and the other group will receive a placebo, which has no active medicine. The study medicine is given one or two times through a small needle in the lower back into the area around the spinal cord. The medicine is designed to lower a protein that builds up in the brains of people with Alzheimer disease. Participants will stay in the research center for a few days during treatment so doctors can watch them closely. They will also need to have a study partner who can go with them to many of the study visits.
We are doing this study to find out if an investigational drug called iptacopan (the study drug) is safe and has beneficial effects for people who have generalized Myasthenia Gravis (gMG).