Clinical Trials Directory
In this study, participants will have different medical tests such as MRI scans, PET scans, heart tests, and exams to check how the brain and body are working. They will stay in the research unit for at least two nights while doctors watch their health closely. The study drug will be given through a vein in the arm. Participants must also have a study partner who can come with them to visits and help during the study.
We are doing this study to find out if an experimental drug called CABA-201 (the study drug) is a safe and effective option for people with systemic sclerosis.
In this study, people may be placed into one of two groups when they join. One group will receive chemotherapy that lowers the immune system before getting the study treatment, and the other group will not. Everyone in the study will receive special CAR T cells that are made to fight disease. After receiving the cells, participants will stay in the hospital for several days so doctors can watch their health closely. They must also stay near the study center for about 45 days and will have regular doctor visits during that time.
In this study, participants will first receive chemotherapy for one to three days to lower their immune system. After that, they will receive special CAR T cells in the hospital and stay there so doctors can watch them closely. For the first month after receiving the cells, participants will be monitored very carefully and must stay near the study center for about 30 days. After that, they will return to the clinic once a month for at least two years so doctors can continue to check their health.
People in this study will be placed into one of two groups by chance, like flipping a coin. One group will get two medicines called DSP107 and Atezolizumab together. The other group will get a medicine called Fruquintinib by itself. Each treatment cycle lasts 4 weeks and can continue for up to 2 years. Doctors will check health and safety during the study. After the last dose, there will be a follow-up period of up to 90 days.