Clinical Trials Directory

459 clinical trials found.
Breast Cancer

We are doing this study to learn how to best support young women making decisions about breast cancer surgery. We want to know what makes women feel uncertain about their decision-making so we can become better at providing the information they need. This study involves testing a web-based decision support tool that is designed to help young women with newly diagnosed breast cancer with their surgical decisions.

Compensation: Yes
Ages: 18-44
Oncology
Remote/online
Breast Cancer

We are doing this study to find out if the use of continuous glucose monitors (CGMs) is worthwhile to help breast cancer patients and their providers monitor for hyperglycemia, or high blood sugar, during chemotherapy. A CGM is a small, wearable sensor that is attached to the skin to frequently measure your blood sugar level, and can share the measurements to your smartphone and to your medical team.

Compensation: Yes
Ages: 18-110
Oncology
Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital
Genitourinary Cancer

We are doing this study to find out if an experimental drug called Actinium-225 rosopatamab tetraxetan (the study drug) is a safe and effective option for patients with castration-resistant prostate cancer (CRPC).

Compensation: No
Ages: 0-64
Oncology
Duke University Hospital
Breast Cancer

We are doing this study to find out if an experimental drug called CRB-601 (the study drug) is a safe and effective option for people who have cancers with advanced solid tumors that did not improve with standard treatment.

Compensation: No
Ages: 18-64
Oncology
Duke University Hospital
Heart and Circulation

This study lasts about 14 weeks and includes 8 planned visits to the clinic. If you qualify during the first part of the study, you will be randomly placed into one of three groups. Each person in the study will get two doses of a medicine called CRD-4730 and one dose that does not contain any medicine, called a placebo. The order of these doses is chosen by chance. Each dose is given over two weeks. You will go to the clinic on the first and last day of each dose. Between each dose, there is a two-week break when you do not take any medicine. During your visits, doctors may do check-ups like physical exams, blood and urine tests, heart tests, stress tests, and more. At home, you will use a device to check your heart every day and write down your results. You will also follow instructions for taking the medicine and keep a diary to record each time you take it.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Breast Cancer

We are doing this study to better understand how breast cancer treatment can affect the heart. In particular, we want to know if treatment with near complete estrogen deprivation (NCED) therapy has an impact on heart function.

Compensation: Yes
Ages: 18-55
Oncology
Duke University Hospital, Duke Raleigh Hospital, Other
Gynecologic Cancer

We are doing this study to find out if using ice with or without compression during chemotherapy can prevent neuropathy for patients being treated for gynecologic cancer.

Compensation: No
Ages: 19-110
Oncology
Duke University Hospital, Duke Raleigh Hospital

We are doing this study to collect cerebrospinal fluid (CSF) samples from people with cancer that has spread to the leptomeninges (the inner membranes that cover the brain and spinal cord). These CSF samples will be used in laboratory research projects to identify substances called biomarkers. Biomarker testing is a way to look for genes, proteins, and other substances (tumor markers) that can provide information about cancer. Information from these CSF samples may help us learn about new methods to treat metastatic disease to the leptomeninges.

Compensation: No
Ages: 18-110
Duke University Hospital