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This study lasts about eight months. After joining, participants will complete an assessment and then be placed into one of two groups by chance. One group will be offered up to 12 counseling sessions with a study therapist over about eight weeks. The other group will be given information about behavioral health services that are already available in the community. Everyone will also receive information about services that can help support health after returning to the community. During the study, participants will have follow up visits over several months and brief check in calls between visits. At these visits, they will answer questions and take part in interviews about their health and substance use. Researchers want to learn if counseling can improve health and well being for people taking part in the study.

People in the study will be split into two groups. One group will take a medicine called IDRX-42 every day as a white tablet. The other group will take a medicine called sunitinib in a capsule for 4 weeks, then stop for 2 weeks, and keep repeating that schedule. Both medicines are taken by mouth with a glass of water. Before starting, each person will have tests to make sure it is safe for them to join the study.

This study lasts about six months. During the study, participants will give blood samples and have simple energy measurements each month. They will also fill out surveys every month about how they are feeling. In months four and five, participants will take part in a short stress activity. This may include several days of heat exposure, slightly less sleep than usual, or exercise.

This study has five parts: screening, treatment, end of treatment, safety check, and long-term follow-up. - Part A: People will try different amounts of a new medicine called KTX-2001 to find the safest dose. - Part B: People will take the best dose of KTX-2001 along with another medicine called darolutamide. KTX-2001 is taken on an empty stomach. Darolutamide is taken with food twice a day. You will get medicine to take at home and write down when you take it in a diary. You will have regular check-ups, scans, heart tests, and maybe a biopsy. After treatment, doctors will check on you for safety and follow up every few months until your cancer gets worse or you start a new treatment.

We are doing this study to learn more about how environmental contaminants (e.g., "forever chemicals") can affect people's likelihood of developing liver disease.

This study doesn't give any treatment. Instead, doctors will collect samples like blood, pee, spit, and a nose swab two times while you're in the hospital. Later, someone from the study will call you after 60 days to ask how you're feeling.

We are doing this study to see if the study drug, PT886, with or without chemotherapy and/or pembrolizumab, is a safe and effective option for gastric and pancreatic cancer. We are also trying to find the best dose of the study drug to use.