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People in this study will be placed into two groups. One group will take three medicines, and the other group will take two medicines and a fake pill. All pills are taken by mouth. At first, visits happen every week, then every month. Some visits may take a long time. The study has different parts and can last up to 5 years, depending on how well the treatment works.

We are doing this study to develop an algorithm to help make accurate decisions about how to manage traumatic wounds. We hope this tool will help us determine the ideal time to use surgery to close major wounds in a way that will best promote healing.

We are doing this study to find out if an experimental drug and device system called X-PACT is a safe and effective treatment for various forms of cancer.

We are doing this study to find out if an experimental drug called XmAb819 (the study drug) is a safe and effective treatment for clear cell renal cell carcinoma (ccRCC).

We are doing this study to determine the impact of smoking electronic cigarettes (e-cigs) on lung health. This will be done by comparing study procedures and imaging results between healthy participants that use e-cigs versus those who don't.

We are doing this study to compare the performance of 2 drugs: zanzalintinib and everolimus. We want to know which option is the most effective for treating neuroendocrine tumors.

We are doing this study to find out if an experimental drug called XTX101 (the study drug) is a safe and effective option for people who have advanced tumors or metastatic microsatellite stable colorectal cancer. We want to see how well it works on its own and in combination with a drug called atezolizumab.

We are doing this study to find out if Non-Ischemic Heart Preservation using an experimental technology called the XVIVO Heart Preservation System (the study technology) is a safe and effective way to preserve extended criteria donor hearts that can be transplanted into patients who need a donor heart. The study technology is designed to preserve donor hearts using a device with a temperature-controlled perfusion solution that flows through the heart during transport. We want to know if this can allow donor hearts to travel a greater distance to patients who are awaiting a transplant.