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This study doesn't give any treatment. Instead, doctors will collect samples like blood, pee, spit, and a nose swab two times while you're in the hospital. Later, someone from the study will call you after 60 days to ask how you're feeling.

We are doing this study to see if the study drug, PT886, with or without chemotherapy and/or pembrolizumab, is a safe and effective option for gastric and pancreatic cancer. We are also trying to find the best dose of the study drug to use.

We are doing this study to see if the study drug, QTX3034, either with or without cetuximab, is safe and effective for treating KRAS G12D mutated cancer. We are also trying to find the best dose of QTX3034 to use.

If you choose to join this study, you will:

• Get 2-6 cycles of Inotuzumab Ozagamicin, lasting 1 month per cycle
• Get Methotrexate on day one during cycle 1 and on day 28 of cycles 2, 4 and 6
• Get about 3-5 mL of blood collected prior to treatment and at three time points during cycle 1 and 4 time points during cycle 2

This study has three smaller parts called Sub Studies. In Sub Study 1, people receive a medicine called duvakitug. In Sub Study 2, people are placed by chance into one of three groups to receive duvakitug or a placebo. In Sub Study 3, people are placed by chance into one of two dose groups to receive duvakitug. The whole study lasts about 35 weeks and includes about 15 visits. During the visits, you will have heart tests, blood tests, an endoscopy with a biopsy, and questionnaires. When you join the study, you will be put into either Sub Study 1 or Sub Study 2. You will take the study medicine every two weeks for 12 weeks. After you finish Sub Study 1 or Sub Study 2, you may be asked to join Sub Study 3 to take duvakitug for another 12 weeks, or you may be asked to join another study called SUNSCAPE 2.

This study has two parts. In the first part, people will be placed into one of three groups by chance. They may receive two doses of a study medicine called SAR447189, one dose of the study medicine and one dose of a placebo, or two doses of a placebo over about forty weeks. After this part, some people may be able to continue into the second part of the study, where everyone will receive the study medicine for a longer time. The full study can last several years. During this time, participants will have many clinic visits. At these visits, doctors will do tests such as heart checks, blood tests, procedures to look inside the body, and ask questions about health and how the person feels.