Directorio

To join this study, you will go to Duke hospital for surgery. During surgery, doctors will place a small tube called a catheter to give you the study medicine and take a tiny piece of tissue for research. After surgery, you will stay in the hospital while the first medicine, called D2C7-IT, goes in for about three days. Then you will get another medicine called 2141-V11, which takes about seven hours. After the medicines are done, the tube will be removed, and you will be watched for six hours. About two weeks later, you will come back to start getting shots of 2141-V11 under your skin. You may keep getting these shots for up to a year, and even longer if you want. When you stop the shots, your doctor will decide what follow-up you need.

We are doing this study to collect information about how well dabrafenib plus trametinib works in patients who have unresectable (cannot be removed by surgery) or metastatic BRAF V600E mutation positive solid tumors.

We are doing this study to collect and store information and samples that will be used for future research studies about transplants.

We are doing this study to collect and store your medical information and specimens for use in future research studies to understand heart function and disease.

We are doing this study to find out how well an emotion regulation skills training program can help expecting mothers lower stress during pregnancy and improve their heart rate.

Participants will receive the study drug injected into an artery within the heart during a procedure in the clinic. They will be followed with visits during the first year, and there is a long term follow up period of 4 years.

The study has a screening period of 8 weeks, a 24 week long treatment period, and a long term extension of 48 weeks where participants can continue to receive the study drug. There are visits approximately 1-2 times a month.

This is a randomized trial, with some participants receiving the study drug and some receiving placebo. The study drug (an oral pill) will be taken daily for 28 days. The total duration of study activities is 9 weeks.