Clinical Trials Directory
This study is testing a new medicine called MYK-224 to help people with a heart problem called HFpEF. That means their heart pumps well but does not relax properly. People in the study also have signs that their heart is not working normally. The study has four groups, called cohorts. Duke is only helping with Cohort 4, which will include about 160 people. These people will be split into four smaller groups. Three groups will get different amounts of the real medicine, and one group will get a fake medicine called a placebo. The treatment will last 20 weeks. A special team of doctors will check to make sure the medicine is safe and decide how much each group should get. To join the study, people must meet certain health rules.
We are doing this study to compare 2 different regimens for treating pancreatic cancer after surgery. We what find out how well patients do after they get a combination of the drugs cevumeran, atezolizumab, and mFOLFIRINOX compared to just getting mFOLFIRINOX alone. Cevumeran is an experimental drug that is made from your own cells that are obtained from blood and tissue samples. It is designed to activate your immune system against cancer cells in your body.
We are doing this study to find out if an experimental drug called avexitide (the study drug) is a safe and effective option to prevent or reduce the severity of hypoglycemia episodes for people who have post-bariatric hypoglycemia following Roux-en-Y gastric bypass.
We are doing this study to find out if a program called AYA STEPS has a positive benefit for young people who are treated for cancer. We want to know how well this program can help cancer survivors younger than 40 manage any physical or emotional symptoms they have after treatment, and we also want to see if the program can help them be more engaged with follow-up care.
If you qualify for the study, a computer will choose your medicine by chance. This means you could get AZD0780 or a pill that does not have medicine, called a placebo. It is like flipping a coin, so you have a 1 in 2 chance of getting AZD0780. Neither you nor your doctor will know which one you get. You will take one pill by mouth every day. Each pill is 30 milligrams. You will visit the study site up to 15 times. These visits will happen at the start and then at different weeks, like week 0, 2, 4, 12, and so on. Each visit will take about 1 to 2 hours. Your doctor will tell you what tests and steps you need to do. Before each visit, you cannot eat or drink anything except water for at least 8 hours. You can drink water during this time.
We are doing this study promote the importance of quitting smoking for pregnant women and to improve how providers can help their patients quit smoking.
We are doing this study to test different drugs to see if they are safe and helpful for adults who are admitted in the hospital with acute respiratory distress syndrome (ARDS) compared to placebo (a substance that looks like a drug but does not contain an active drug).
We are doing this study to compare the outcomes of 2 treatments for women with stress urinary incontinence (SUI): transurethral bulking agent (TBA) and single-incision sling (SIS). Both treatments are FDA-approved and can help improve SUI symptoms, but they have not been directly compared to each other to see which treatment is better for certain patients and under what circumstances. We hope this study can help women and their doctors find out which option is most likely to have the best results. Current evidence suggests that TBA and SIS are less effective than a traditional full-length mid-urethral sling procedure, but both options are less invasive and less likely to cause complications afterward.