Clinical Trials Directory

We are doing this study to understand how different factors, such as pain experiences and inflammation, may affect how acute back pain transitions to chronic back pain.

We are doing this study to find the most effective, safe dose of an experimental drug called iadademstat (the study drug). We want to know if the study drug is beneficial for people with R/R AML that have the FLT3 mutation when it is given in combination with gilteritinib.

We want to compare two ways to help older adults check their blood pressure at home. One way includes help from a pharmacist, and the other does not. We want to see which way works better for lowering blood pressure in people who have more than one health problem.

This study needs two overnight stays to give a special medicine called choline and to make sure it is safe. It also includes ten visits to the clinic over about sixteen months.

If you join this study, you will be randomly placed into one of two groups - one group will get the study medicine, and the other will get a placebo, which is a fake medicine. You will give yourself a shot once a week. The amount of medicine in the shot will go up every 4 weeks, starting at a small dose and going up to a bigger dose. The study may last up to 12 months. During that time, doctors will check your health with tests like: - Measuring your height, weight, and vital signs - Taking blood samples - Doing pregnancy tests - Doing a spinal tap at the beginning and end of the study - Eye exams - Brain and nerve check-ups - Surgery check-ups - Help with nutrition, exercise, and healthy habits - Keeping a diary about headaches and medicine - Answering questions in surveys

We are doing this to compare the results of early surgical intervention to medical therapy. We want to know if there is a difference in outcomes for these treatment options. We also want to track the health and progress of people with a large ascending aortic aneurysm (a bulge in the aorta caused by weakening in the artery wall).