Clinical Trials Directory

We are doing this study to compare 2 different treatment options for endometrial intraepithelial neoplasia (EIN) in the uterus. We want to find out if the combination of metformin and megestrol acetate can decrease the growth of EIN better than megestrol on its own. We will compare how well both options work for women who are planning to either have a hysterectomy or have an intrauterine device (IUD) placed.

We are doing this study to look at blood, tumor, and lymph node tissue from people with melanoma so we can improve diagnostic methods and therapies for people with melanoma.

We are doing this study to learn more about the symptoms of menopause in women with sickle cell disease (SCD). We want to learn more about how hydroxyurea, pain, and other SCD-related complications can affect their menopause experience. We hope this study can help us more quickly and easily find out when women with SCD might be experiencing health complications related to menopause.

We are doing this study to find out if the study drug, pembrolizumab, is a safe and effective treatment for metastatic castrate-resistant prostate cancer when it is given in different combinations with other drugs. Pembrolizumab may work by increasing your immune system's response against a tumor.

We are doing this study to find the most effective, safe dose of an experimental drug called V940 (the study drug) when it is given with pembrolizumab to people who have had surgery to remove renal cell carcinoma. We want to know how well this combination works compared to taking pembrolizumab on its own.

We are doing this study to find the most effective, safe dose of an experimental drug called bomedemstat (the study drug) for people with essential thrombocythemia who are unable to take hydroxyurea or do not get a benefit from it.

We are doing this study to compare 2 different approaches to help people quit smoking. We want to know which of these approaches is most likely to help smokers who have a mental illness and want to stop smoking.

We are doing this study to learn more about how well a study intervention works to reduce distress caused by misophonia. This intervention combines neurostimulation and skills-based training that is designed to help people think differently.