Clinical Trials Directory
We are doing this study to find out if an experimental drug called XC001 (the study drug) is an effective option for people who have angina that is caused by coronary artery disease. We want to know if the study drug can provide relief when common, approved therapies have failed to do so. The study drug is made using an adenovirus (one of the causes of the common cold). The adenovirus in the study drug is genetically altered so it is able to deliver a protein called VEGF (vascular endothelial growth factor) to the heart and potentially spur the growth of new blood vessels.
In this study, people will get a new kind of eye transplant. They'll be randomly chosen (like flipping a coin) to get either a special treated cornea or a regular one. Doctors will check on them for 2 years after the transplant to see how they're doing and to watch for any side effects.
This study is about helping astronauts stay safe during moonwalks. When astronauts go to the moon, they wear special suits with lower air pressure, which can cause small bubbles to form in the body. These bubbles can cause a problem called decompression sickness, which may lead to pain or weakness. To help prevent this, astronauts breathe pure oxygen before their moonwalk. In this study, people will breathe oxygen for about one hour while resting or doing different levels of exercise. After that, they will enter a special room that lowers air pressure to feel like being in a spacesuit. While inside, they will do light exercises and have ultrasound tests to look for bubbles in the body. This part lasts about six hours. The goal is to learn how well oxygen breathing and activity help prevent decompression sickness.
We are doing this study to evaluate an experimental technology called the Reprieve Decongestion Management System (the study device) for heart failure patients with fluid overload. The study device is designed to help people with heart failure feel better by removing extra fluid from their body quickly. The device is programmed to deliver an appropriate amount of medication at the right time to help people shed extra fluid through urination. We want to know if this device works better than the standard treatment. The standard treatment is to prescribe diuretics (medication to increase urination) at a specified dose and dosage schedule.