Purpose of this Study
We are doing this study to learn more about the causes of unsuccessful pregnancies. We want to compare samples of endometrial tissue from women who have experienced infertility with samples from women who have had children without fertility treatment. We hope this can help improve future options for women who are having difficulty with pregnancy.
Who Can Participate?
Eligibility
Women ages 18-42 who:<ul>
<li>Have had at least 1 successful pregnancy without the use of fertility treatment or have undergone IVF only because of male infertility; OR</li>
<li>Have undergone IVF that has resulted in at least 2 negative pregnancy tests, or at least 2 biochemical pregnancies, or at least 2 pregnancy losses</li></ul>
We cannot enroll anyone who is currently pregnant, uses any type of tobacco product, has a BMI (body mass index) above 30, or has any history of a cancerous or precancerous condition of their reproductive tract.
For more information, please contact the study team at <a href= "mailto: caroline.nagle@duke.edu">caroline.nagle@duke.edu.</a>
<li>Have had at least 1 successful pregnancy without the use of fertility treatment or have undergone IVF only because of male infertility; OR</li>
<li>Have undergone IVF that has resulted in at least 2 negative pregnancy tests, or at least 2 biochemical pregnancies, or at least 2 pregnancy losses</li></ul>
We cannot enroll anyone who is currently pregnant, uses any type of tobacco product, has a BMI (body mass index) above 30, or has any history of a cancerous or precancerous condition of their reproductive tract.
For more information, please contact the study team at <a href= "mailto: caroline.nagle@duke.edu">caroline.nagle@duke.edu.</a>
Age Range
18-42
Sex/Genders
Female (cisgender)
Looking for Healthy Participants
Yes
What is Involved?
If you have had a child without needing fertility treatment and choose to join this study, you will:<ul>
<li>Make a screening visit to our clinic to confirm that you are eligible</li>
<li>Have endometrial biopsies during 2 separate menstrual cycles</li></ul>
If you have made at least 2 attempts using vitro fertilization (IVF) without success and join this study, you will:<ul>
<li>Make a screening visit to our clinic to confirm that you are eligible</li>
<li>Have an endometrial biopsy</li></ul>
<li>Make a screening visit to our clinic to confirm that you are eligible</li>
<li>Have endometrial biopsies during 2 separate menstrual cycles</li></ul>
If you have made at least 2 attempts using vitro fertilization (IVF) without success and join this study, you will:<ul>
<li>Make a screening visit to our clinic to confirm that you are eligible</li>
<li>Have an endometrial biopsy</li></ul>
Locations
Other
Visit Timing
Weekdays
Compensation
Yes
Spanish Materials Available
No
Study Details
Full Title
Endometrial Basis for Infertility in Women with Recurrent Implantation Failure and Pregnancy Loss
Principal Investigator
Danny
Schust
Protocol Number
PRO00111733
NCT ID
NA
Phase
N/A
Enrollment Status
Pending Open to Enrollment