U01 Endometrial Basis for RIF and PL (Infertility)

Purpose of this Study

We are doing this study to learn more about the causes of unsuccessful pregnancies. We want to compare samples of endometrial tissue from women who have experienced infertility with samples from women who have had children without fertility treatment. We hope this can help improve future options for women who are having difficulty with pregnancy.

Who Can Participate?

Eligibility

Women ages 18-42 who:
  • Have had at least 1 successful pregnancy without the use of fertility treatment or have undergone IVF only because of male infertility; OR
  • Have undergone IVF that has resulted in at least 2 negative pregnancy tests, or at least 2 biochemical pregnancies, or at least 2 pregnancy losses
We cannot enroll anyone who is currently pregnant, uses any type of tobacco product, has a BMI (body mass index) above 30, or has any history of a cancerous or precancerous condition of their reproductive tract. For more information, please contact the study team at caroline.nagle@duke.edu.

Age Range

18-42

Sex/Genders

Female (cisgender)
Looking for Healthy Participants
Yes

What is Involved?

Description

If you have had a child without needing fertility treatment and choose to join this study, you will:
  • Make a screening visit to our clinic to confirm that you are eligible
  • Have endometrial biopsies during 2 separate menstrual cycles
If you have made at least 2 attempts using vitro fertilization (IVF) without success and join this study, you will:
  • Make a screening visit to our clinic to confirm that you are eligible
  • Have an endometrial biopsy

Locations

Other

Visit Timing

Weekdays

Compensation

Yes

Spanish Materials Available

No

Study Details

Full Title

Endometrial Basis for Infertility in Women with Recurrent Implantation Failure and Pregnancy Loss

Principal Investigator

Danny
Schust

Protocol Number

PRO00111733

NCT ID

NA

Phase

N/A

Enrollment Status

Pending Open to Enrollment
ClinicalTrials.gov