Purpose of this Study
This study lasts about three months. People will first have two screening visits to see if they can join. They will then receive five days of treatment in a row. After treatment, they will return for follow up visits about one week, one month, and three months later.
Participants will be placed into one of two groups by chance and will receive different doses of a treatment called transcranial magnetic stimulation. This treatment uses magnets placed outside the head and does not require surgery. During the study, participants will answer questions about their pain and daily life, have a brain MRI scan, and complete tests that measure sensation and brain function.
The goal is to learn if this treatment can help reduce long lasting pain after a stroke.
Who Can Participate?
Eligibility
People may be able to join this study if they are 21 years old or older and had a stroke that affected a part of the brain called the thalamus at least six months ago. They must still have ongoing pain after the stroke even though they have tried at least two pain medicines. Participants must be able to understand the study and agree to take part. People cannot join if they have a history of seizures or another major long term pain condition that could affect the study results.
Age Range
18-110
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No
What is Involved?
Description
This study is being done to find out if a new treatment that uses magnetic stimulation of the brain can help reduce long lasting pain after a stroke. The treatment does not require surgery and works from outside the body. Researchers also want to learn if brain scans called MRI scans can help predict which people are most likely to benefit from the treatment. The goal is to improve future treatment options for people who have central post stroke pain.
Locations
Duke University Hospital
Visit Timing
Weekdays
Weekends
Evenings
Compensation
Yes
Spanish Materials Available
No
Study Details
Full Title
ACCELERATED THETA-BURST STIMULATION FOR THE TREATMENT OF REFRACTORY CENTRAL POST-STROKE PAIN: A PILOT TRIAL
Principal Investigator
Salman
Ikramuddin
Protocol Number
PRO00120689
NCT ID
NA
Phase
Pilot
Enrollment Status
Pending Open to Enrollment