Purpose of this Study
We are doing this study to get a better understanding of what predicts severe pain in teenagers and young adults living with sickle cell disease.
Who Can Participate?
Eligibility
Adults and children ages 15-40 who:<ul>
<li>Are diagnosed with sickle cell disease</li>
<li>Have used a strong pain medication, like morphine or oxycodone, in the past 12 months to treat a sickle cell pain crisis either at home or in the hospital</li>
<li>Are not pregnant</li>
<li>Have never received gene therapy or a bone marrow transplant</li></ul>
For more information about who can be in this study, please contact the study team at <a href= "mailto: omowunmi.olaleye@duke.edu">omowunmi.olaleye@duke.edu.</a>
<li>Are diagnosed with sickle cell disease</li>
<li>Have used a strong pain medication, like morphine or oxycodone, in the past 12 months to treat a sickle cell pain crisis either at home or in the hospital</li>
<li>Are not pregnant</li>
<li>Have never received gene therapy or a bone marrow transplant</li></ul>
For more information about who can be in this study, please contact the study team at <a href= "mailto: omowunmi.olaleye@duke.edu">omowunmi.olaleye@duke.edu.</a>
What is Involved?
If you choose to join this study, you will:<ul>
<li>Fill out surveys about your health, mood, and pain</li>
<li>Undergo standard pain testing that uses different sensations</li></ul>
One test involves pressure, and it uses a tool that pushes firmly against your skin. Another test involves heat, and it uses a tool that slowly becomes warm. The final test sees how you respond to "pin pricks," and it uses a tool with a sharp end like a safety pin.
The pain tests are important for showing us how your brain "sees" pain. They may be slightly uncomfortable, but they are safe, they cause no damage, and you can stop the tests whenever you want.
<li>Fill out surveys about your health, mood, and pain</li>
<li>Undergo standard pain testing that uses different sensations</li></ul>
One test involves pressure, and it uses a tool that pushes firmly against your skin. Another test involves heat, and it uses a tool that slowly becomes warm. The final test sees how you respond to "pin pricks," and it uses a tool with a sharp end like a safety pin.
The pain tests are important for showing us how your brain "sees" pain. They may be slightly uncomfortable, but they are safe, they cause no damage, and you can stop the tests whenever you want.
Study Details
Full Title
Predictors of Pain Severity and Pain-Related Outcomes in Individuals with Sickle Cell Disease
Principal Investigator
Martha
Kenney
Protocol Number
PRO00112024
NCT ID
NCT06139510
Phase
N/A
Enrollment Status
Open to Enrollment