Purpose of this Study
We are doing this study to determine the impact of smoking electronic cigarettes (e-cigs) on lung health. This will be done by comparing study procedures and imaging results between healthy participants that use e-cigs versus those who don't.
Who Can Participate?
Eligibility
Adults ages 18-35 who are in general good health can participate as either e-cigarette users or non-users if they meet the following criteria:
E-cigarette users
- Have used e-cigarettes for at least 6 months
- Do not have more than a 1 pack year history of smoking traditional tobacco cigarettes (1 pack year = smoking 1 pack of cigarettes per day for 1 year)
- Have no history of lung, kidney, or liver disease
- Have no history of stroke, brain damage, or dementia
- Are not pregnant
- Have never used e-cigarettes and do not currently smoke
- Do not have more than a 1 pack year history of smoking traditional tobacco cigarettes (1 pack year = smoking 1 pack of cigarettes per day for 1 year)
- Have no history of lung, kidney, or liver disease
- Have no history of stroke, brain damage, or dementia
- Are not pregnant
Age Range
18-35
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
Yes
What is Involved?
Description
If you choose to join this study, it will involve 5 study visits, lasting up to 4 hours each. This includes a screening visit and 4 procedure visits, with the last 2 visits at a 12- month follow-up.
Study procedures will include:
- Cardiopulmonary exercise testing
- Pulmonary function testing
- Electrocardiograms
- Multiple dimensional computed tomography
- Physical exam and basic body measurements such as temperature, heart rate, and blood pressure
- Blood and urine collection
- Health questionnaires
- Hyperpolarized xenon magnetic resonance imaging (this is a special type of MRI where you breathe in a small bag of xenon gas and hold your breath while in the MRI scanner)
Locations
Duke University Hospital
Visit Timing
Weekdays
Compensation
Yes
Spanish Materials Available
No
Study Details
Full Title
Dissolved Phase Hyperpolarized Xenon-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology in Young Healthy E-cigarette Users
Principal Investigator
Joseph
Mammarappallil
Protocol Number
PRO00116167
NCT ID
NCT06856525
Phase
II
Enrollment Status
Open to Enrollment