Purpose of this Study
We are doing this study to find out how common it is for exocrine pancreatic insufficiency (EPI) to be present in children who have or are suspected to have celiac disease. We also want to compare different methods of testing for EPI in this study.
Who Can Participate?
Eligibility
Children ages 0-17 who:
- Have a documented abnormal celiac serology test (elevated blood antibody levels that are associated with celiac disease)
- Are scheduled to have an upper endoscopy to get a biopsy to confirm celiac disease
- Have not started a gluten-free diet before having their diagnostic endoscopy
Age Range
0-17
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No
What is Involved?
Description
If your child choose to join this study with your permission, they will have their routine endoscopy performed to confirm whether or not they have celiac disease. This endoscopy will include endoscopic pancreatic function testing, which is also a routine, common test. Pancreatic fluid will be collected during the procedure following intravenous secretin administration. Additional research analysis will be conducted on the excess pancreatic fluid samples that would otherwise be discarded.
Locations
Duke University Hospital
Other
Visit Timing
Weekdays
Compensation
No
Spanish Materials Available
No
Study Details
Full Title
Prospective Evaluation of Exocrine Pancreatic Insufficiency in Pediatric Patients with Celiac Disease Using Endoscopic Pancreatic Function Testing
Principal Investigator
Arun
Ajmera
Protocol Number
PRO00117604
NCT ID
NA
Phase
N/A
Enrollment Status
Pending Open to Enrollment