Purpose of this Study
We are doing this study to learn more about why some people develop pain syndromes after a stroke. We want to find out if certain brain areas, like the ventral posterior lateral nucleus of the thalamus and its connections, are linked to this pain.
Who Can Participate?
Eligibility
Adults ages 21+ who:
- Have experienced only 1 ischemic or hemmorhagic stroke that affects the thalamus (prior silent infarct or minor stroke with complete recovery is acceptable)
- Have an NIHSS sensory test scored of 1 (partial sensory loss) or 2 (complete sensory loss) at the time of consent of joining the study
- Have a pre-stroke modified Rankin Scale (mRS) of 2 or lower
Age Range
21-110
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No
What is Involved?
Description
If you choose to join the study, you will have a checkup by the study doctor and team to make sure that it is safe for you to have MRI scans.
The first study visit will happen while you are still in the hospital. At this visit, you will have an exam, do sensory tests, and answer questionnaires from the study team. At each following study visit, the study procedures will be explained to you by the study staff at the beginning of each visit. Then you will fill out several questionnaires about how you are feeling after your stroke and if you have pain.
During the first study visit, you will:
- Sign a consent form to join the study after all of your questions have been addressed
- Have an exam by the study doctor
- Have sensory testing
- Answer questionnaires about how you feel and any pain you might have
- Have transcranial magnetic stimulation - this procedure is optional, we do it to test the excitability of neurons over parts of the surface of the brain
- Have sensory testing
- Answer questionnaires about how you feel and any pain you might have
- Have transcranial magnetic stimulation - this procedure is optional, we do it to test the excitability of neurons over parts of the surface of the brain
- Have sensory testing
- Answer questionnaires about how you feel and any pain you might have
- Have transcranial magnetic stimulation - this procedure is optional, we do it to test the excitability of neurons over parts of the surface of the brain
Locations
Duke University Hospital
Visit Timing
Weekdays
Compensation
Yes
Spanish Materials Available
No
Study Details
Full Title
Predicting and developing biomarkers for post-stroke thalamic pain syndrome ? A Pilot Study
Principal Investigator
Wuwei
Feng
Protocol Number
PRO00117033
NCT ID
NA
Phase
N/A
Enrollment Status
Pending Open to Enrollment