Purpose of this Study
We are doing this study to compare 3 different kinds of brain training to find out which is most effective in improving cognitive outcomes and everyday functioning for people with mild cognitive impairment or memory loss.
Who Can Participate?
Eligibility
Adults ages 55-89 who:
- Are diagnosed with mild cognitive impairment (MCI) OR do not have a diagnosis of MCI but are experiencing memory loss that is worse than what's expected from normal aging
- Are willing and able to have 2 brain MRI scans
- Have a study partner who can provide information about their everyday function
- Have access to a computer or tablet
- Do not have a diagnosis of dementia
- Do not do crossword puzzles on a regular basis
Age Range
55-89
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No
What is Involved?
Description
If you choose to join this study, you will come in for a screening visit to make sure that you are eligible to participate. During this visit, you will have an MRI scan taken of your brain and do some cognitive testing. If you are eligible to continue, you will get a random assignment (like drawing numbers from a hat) to 1 of 3 brain training groups. Your group assignment might be:
- High-frequency puzzles: If you are in this group, you will do crossword puzzles provided by the study team 4 times per week. OR
- Low-frequency puzzles: If you are in this group, you will do 1 crossword puzzle provided by the study team each week. OR
- Health education: If you are in this group, you will get a book that discusses how health conditions and lifestyle can affect health. The study team will give your reading assignments from this book during the study.
Locations
Duke University Hospital
Visit Timing
Weekdays
Compensation
Yes
Spanish Materials Available
No
Study Details
Full Title
Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 trial.
Principal Investigator
Pudugramam
Doraiswamy
Protocol Number
PRO00116036
Phase
N/A
Enrollment Status
Pending Open to Enrollment