If you choose to join this study, you will go through a screening period to find out if you are eligible. During this screening period, you will:

• Have a physical exam
• Have a heart scan (ECG)
• Have blood draws and give urine samples
• Have bone marrow samples taken
• Have images taken (X-ray or CT scan)
• Have a Lumbar puncture/tumor biopsy

If you are eligible to continue after screening, you will be scheduled for a procedure called leukapheresis to collect some of your white blood cells. After your cells are collected, they will be sent to a laboratory to be genetically modified to become activated and kill the lymphoma cells. Before you are treated with these modified CAR T-cells, you will receive fludarabine and cyclophosphamide as conditioning therapy for 3 days. You will check in to the hospital before the infusion of the CAR T-cells and stay for at least 24 hours afterward. You might stay in the hospital for a longer period of time to be monitored if you are one of the first 20 participants in the study. After you check out of the hospital, you will:

• Visit our clinic every day until it has been 14 days since your CAR-T infusion
• Visit our clinic weekly once it has been 14 days since your CAR-T infusion
• Visit our clinic every 3 months once it has been 28 days since your CAR-T infusion
• Visit our clinic every 6 months once it has been 1 year since your CAR-T infusion
• Stop coming in for follow-up visits once it has been 2 years since your CAR-T infusion