Purpose of this Study
We are doing this study to learn how to get the best quality images of lungs in an MRI scanner as people breathe in Xenon gas. We hope this imaging will show key differences between diseased and healthy lungs.
Who Can Participate?
Eligibility
Adults ages 18+ who:
- Are diagnosed with an interstitial lung disease; OR
- Are in general good health and do not have lung disease (healthy, matching volunteers)
Age Range
18-90
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
Yes
What is Involved?
Description
If you join the study, you will:
- Have 1 visit that will last 2-3 hours, with an optional second visit about 1 week later
- Answer health questionnaires
- Have your blood pressure, temperature, and breathing
- Be scanned in an MRI machine while breathing in gas
- Receive compensation for participation
Locations
Duke University Hospital
Visit Timing
Weekdays
Compensation
Yes
Spanish Materials Available
No
Study Details
Full Title
Optimizing and Standardizing 129Xe Gas Exchange MRI to Visualize Regional Therapy Response in Interstitial Lung Disease
Principal Investigator
Joseph
Mammarappallil
Protocol Number
PRO00107570
NCT ID
NCT04855305
Phase
II
Enrollment Status
Open to Enrollment