DEPTH Trial (Emphysema in People Living with HIV)

DEPTH Trial (Emphysema in People Living with HIV)

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Purpose of this Study

If you choose to join this study, you will complete up to 10 study visits and 2 phone call check-ins over 72 weeks. This study includes:
  • Pulmonary function tests (how well your lungs are working)
  • CT scans of the chest (a special type of imaging that creates 3D X-ray images)
  • Blood draws
  • Questionnaires
During the study, you will be randomized (like flipping a coin) to get either:
  • The study drug (Doxycycline) by mouth twice a day for 72 weeks; OR
  • A placebo (sugar pill) by mouth twice a day for 72 weeks
  • Who Can Participate?

    Eligibility

    Adults ages 30+ who:
    • Are living with HIV
    • Have smoking-related lung disease
    For more information about who can join this study, please contact the study team at depth-trial@duke.edu or 919-684-2285.

    Age Range

    30-110

    Sex/Genders

    Male (cisgender)
    Female (cisgender)
    Non-binary or gender fluid
    Transgender male
    Transgender female
    Looking for Healthy Participants
    No

    What is Involved?

    Description

    We are doing this study to learn more about whether Doxycycline (an antibiotic medication) will help slow the progression of emphysema, or COPD.

    Locations

    Duke University Hospital

    Visit Timing

    Weekdays

    Compensation

    Yes

    Spanish Materials Available

    No

    Study Details

    Full Title

    Doxycycline for Emphysema in People Living with HIV (The DEPTH Trial)

    Principal Investigator

    David
    Murdoch

    Protocol Number

    PRO00111021

    NCT ID

    NCT05382208

    Phase

    II

    Enrollment Status

    Open to Enrollment