Purpose of this Study
Participants will be randomly assigned to receive either methylprednisolone before surgery or no methylprednisolone before surgery. Researchers will collect information about recovery, side effects, tests, and procedures for about 30 days after surgery. The information will be added to a research database to compare outcomes between the two groups and evaluate the effectiveness of the treatment.
Who Can Participate?
Eligibility
Participants may be able to join if they are adults age 18 or older who are scheduled to undergo a major liver surgery called a hepatectomy. Researchers are studying whether receiving methylprednisolone before surgery can help reduce side effects and improve recovery after the procedure.
Age Range
18-110
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No
What is Involved?
Description
This study is testing whether giving methylprednisolone before surgery can reduce side effects and improve recovery after surgery. Methylprednisolone is a steroid medicine that helps reduce inflammation and calm the immune system. Researchers will compare people who receive the medication before surgery with those who do not to see if it improves outcomes.
Locations
Duke University Hospital
Visit Timing
Weekdays
Compensation
No
Spanish Materials Available
No
Study Details
Full Title
A Randomized Controlled Trial of Methylprednisolone vs No Steroid in Patients
Undergoing Elective Major Hepatectomy
Undergoing Elective Major Hepatectomy
Principal Investigator
Michael
Lidsky
Protocol Number
PRO00120818
NCT ID
NCT07507643
Phase
III
Enrollment Status
Pending Open to Enrollment