Purpose of this Study
This study does not give any medicine or treatment. Instead, it includes a few short visits over about four weeks. People who join will go to the clinic up to three times.
During the first visit, they will sign forms, talk about their health history, get a physical exam, have their blood pressure checked, and give blood and urine samples without needing to fast.
For the second visit, they will take a small pill called dexamethasone at home the night before. Then they will come back to the clinic for a blood test while fasting. This test checks hormone levels.
Some people may need a third visit. If their hormone levels are high, they will give more blood and schedule a special scan of their adrenal glands.
This study is not a treatment study. It is meant to help doctors learn more about hormone levels in people with hard-to-control high blood pressure.
Who Can Participate?
Eligibility
Adults who are 18 years old or older may be able to join this study if they have resistant high blood pressure. This means their blood pressure stays high even though they take three or more medicines, including one that helps remove extra water from the body. Some people may need four or more different kinds of medicine to keep their blood pressure under control.
To join, they must be able to take a medicine called dexamethasone for testing. People with certain health problems cannot join because these problems could affect the test results. These include conditions like Cushing syndrome, congenital adrenal hyperplasia, serious sleep problems that are not treated, or recent use of steroid medicines. Women who are pregnant or taking birth control pills must meet extra rules to be part of the study.
Age Range
18-110
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No
What is Involved?
Description
The purpose of this study is to learn how often a hormone problem called endogenous hypercortisolism happens in people who have resistant high blood pressure. This kind of blood pressure stays high even when people take several medicines. By studying this condition, scientists hope to help doctors understand it better and find ways to help patients whose blood pressure is hard to control.
Locations
Duke University Hospital
Other
Visit Timing
Weekdays
Compensation
Yes
Spanish Materials Available
No
Study Details
Full Title
Study of the Prevalence of Endogenous Hypercortisolism in Patients with Resistant Hypertension (MOMENTUM)
Principal Investigator
Nishant
Shah
Protocol Number
PRO00118199
NCT ID
NCT06829537
Phase
IV
Enrollment Status
Pending Open to Enrollment