Purpose of this Study
We are doing this study to learn more about the rare diagnosis of New Daily Persistent Headache (NDPH). We want to get more information about why some children and young people develop this condition and how it is different from traditional headaches, like migraines. This knowledge can help us to begin developing possible treatments for NDPH.
Who Can Participate?
Eligibility
Adolescents ages 12-18 who:<ul>
<li>Are diagnosed with or suspected to have NDPH</li>
<li>Have no history of Raynaud's syndrome</li>
<li>Have no history of concussion or neurosurgery</li></ul>
Healthy adolescents with no medical issues or adolescents with a history of normal migraine headaches can also join the study as control participants and give a blood sample.
For more information, please contact the study team at <a href= "mailto: brittany.nave@duke.edu">brittany.nave@duke.edu.</a>
<li>Are diagnosed with or suspected to have NDPH</li>
<li>Have no history of Raynaud's syndrome</li>
<li>Have no history of concussion or neurosurgery</li></ul>
Healthy adolescents with no medical issues or adolescents with a history of normal migraine headaches can also join the study as control participants and give a blood sample.
For more information, please contact the study team at <a href= "mailto: brittany.nave@duke.edu">brittany.nave@duke.edu.</a>
Age Range
12-18
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
Yes
What is Involved?
If you choose to have your child join this study, they will:<ul>
<li>Visit our clinic 2 times</li>
<li>Have an exam</li>
<li>Have blood draws</li>
<li>Answer questionnaires</li>
<li>Keep a diary of their headache symptoms for 4 months</li></ul>
The visits to our clinic for this study will be about 4 months apart. Their study participation will end after the second visit. The study doctor might suggest some headache remedies to try during their time in the study.
<li>Visit our clinic 2 times</li>
<li>Have an exam</li>
<li>Have blood draws</li>
<li>Answer questionnaires</li>
<li>Keep a diary of their headache symptoms for 4 months</li></ul>
The visits to our clinic for this study will be about 4 months apart. Their study participation will end after the second visit. The study doctor might suggest some headache remedies to try during their time in the study.
Locations
Duke University Hospital
Visit Timing
Weekdays
Compensation
No
Spanish Materials Available
No
Study Details
Full Title
New Daily Persistent Headache (NDPH): Biomarker study and therapy in children and adolescents.
Principal Investigator
Klaus-Georg
Werner
Protocol Number
PRO00113907
NCT ID
NCT06018025
Phase
N/A
Enrollment Status
Open to Enrollment