Study drug RO7589831 for MSI/dMMR solid tumors (BP44474)

Purpose of this Study

We are doing this study to find out if an experimental drug called RO7589831 (the study drug) is a safe and effective option for cancers with solid tumors. We also want to find out what the best dose of the study drug is in this study.

Who Can Participate?

Eligibility

Adults ages 18+ who:
<li>Are diagnosed with advanced cancer that worsened after at least 1 prior line of standard therapy</li>
<li>Have had a tumor sample test positive for microsatellite instability or mismatch repair deficiency</li></ul>
For more information about this study, please contact the study team at 919-668-1861 or gi-oncology-cru@dm.duke.edu.

What is Involved?

If you choose to join this study, you will:<ul>
<li>Take the study drug every day (it is taken by mouth)</li>
<li>Have your tumor biopsied</li>
<li>Give blood and urine samples</li>
<li>Have regular CT or MRI scans</li></ul>

Study Details

Full Title

[BP44474] A phase I, open-label study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and anti-tumor activity of RO7589831 in participants with advanced solid tumors harboring microsatellite instability (MSI) and/or deficient mismatch repair (dMMR)

Principal Investigator

John
Strickler

Protocol Number

PRO00113812

NCT ID

NCT06004245

Phase

I

Enrollment Status

Open to Enrollment