Purpose of this Study
We are doing this study to collect cerebrospinal fluid (CSF) samples from people with cancer that has spread to the leptomeninges (the inner membranes that cover the brain and spinal cord). These CSF samples will be used in laboratory research projects to identify substances called biomarkers. Biomarker testing is a way to look for genes, proteins, and other substances (tumor markers) that can provide information about cancer. Information from these CSF samples may help us learn about new methods to treat metastatic disease to the leptomeninges.
Who Can Participate?
Eligibility
Adults ages 18+ who:<ul>
<li>Have a suspected or confirmed diagnosis of metastatic disease to the leptomeninges</li>
<li>Are not participating in another CSF biobanking study at Duke</li>
<li>Are not pregnant</li></ul>
For more information about who can join this study, please contact one of the study team members below:
Dorothy Sipkins, MD, PhD : <a href= "mailto: dorothy.sipkins@duke.edu">dorothy.sipkins@duke.edu</a> or 919-613-5010
Olivia Cupelli: <a href= "mailto: olivia.cupelli@duke.edu">olivia.cupelli@duke.edu</a> or 919-668-1211
<li>Have a suspected or confirmed diagnosis of metastatic disease to the leptomeninges</li>
<li>Are not participating in another CSF biobanking study at Duke</li>
<li>Are not pregnant</li></ul>
For more information about who can join this study, please contact one of the study team members below:
Dorothy Sipkins, MD, PhD : <a href= "mailto: dorothy.sipkins@duke.edu">dorothy.sipkins@duke.edu</a> or 919-613-5010
Olivia Cupelli: <a href= "mailto: olivia.cupelli@duke.edu">olivia.cupelli@duke.edu</a> or 919-668-1211
Age Range
18-110
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No
What is Involved?
If you choose to join the study, you will:<ul>
<li>Have your medical record reviewed</li>
<li>Have an extra 5ml (1 teaspoon) of CSF taken at times when you are having a routine lumbar puncture done</li></ul>
<li>Have your medical record reviewed</li>
<li>Have an extra 5ml (1 teaspoon) of CSF taken at times when you are having a routine lumbar puncture done</li></ul>
Locations
Duke University Hospital
Visit Timing
Weekdays
Compensation
No
Spanish Materials Available
No
Study Details
Full Title
Cerebrospinal Fluid Repository in Adults with Presumed or Diagnosed Metastatic Disease to the Leptomeninges
Principal Investigator
Dorothy
Sipkins
Protocol Number
PRO00113662
Enrollment Status
Open to Enrollment