UNC ACL PTOA: A Study of Recovery after Anterior Cruciate Ligament (ACL) Reconstruction

Purpose of this Study

We are doing this study to get a better understanding of why people are at higher risk of developing arthritis after ACL reconstruction surgery. We hope the information from this study can help improve recovery techniques and lower the risk of developing knee arthritis for people who have ACL surgery. We are partnering with UNC-Chapel Hill to do this study.

Who Can Participate?

Eligibility

Adults and children ages 16-35 who:<ul>
<li>Have an ACL tear and are planning to have ACL reconstruction surgery at Duke; OR</li>
<li>Had a previous ACL tear and reconstruction surgery and are planning to have a revision surgery at Duke</li></ul>
For more information about who can join this study, please contact the study team at cassandra.rhodes@duke.edu.

Age Range

18-50

Sex/Genders

Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No

What is Involved?

If you choose to join this study, you will visit a study clinic at UNC one time before your surgery to have some physical assessments done for your injured leg. You will return to the UNC clinic for 4 follow-up visits at the following times: 2, 4, 6, and 12 months after your surgery. During these follow-up visits, you will:<ul>
<li>Have blood draws</li>
<li>Give urine samples</li>
<li>Answer questionnaires</li>
<li>Have images (MRI and X-ray) taken of your injured knee and leg</li>
<li>Do a variety of physical movement and strength tests</li></ul>
We will pay you for your time on the study.

Locations

Duke University Hospital
Other

Visit Timing

Weekdays

Compensation

Yes

Spanish Materials Available

No

Study Details

Full Title

Biomechanical Changes Following ACL Injury that Influence PTOA

Principal Investigator

Brian
Lau

Protocol Number

PRO00111706

Phase

N/A

Enrollment Status

Open to Enrollment