Purpose of this Study
This study is looking for healthy people between 18 and 21 years old who have never smoked a whole cigarette or used any tobacco products like vaping, blunts, or hookah. The study has 1 online visit and 6 in-person visits. These visits include a remote screening, a training visit, a brain scan (called fMRI), 3 test sessions, and a choice session. During the test sessions, blood will be taken to check nicotine levels. You will also give urine samples to check for drugs and pregnancy if needed. People who finish everything can earn up to $925.
Who Can Participate?
Eligibility
To join this study, you must be between 18 and 21 years old. You cannot have used tobacco in the past year or smoked cigarettes or other tobacco products more than 10 times in your life. You also cannot have taken certain medicines like antidepressants, ADHD medicine, pain medicine with opioids, or mood stabilizers in the past 60 days. Finally, you cannot have any health conditions that would make a brain scan (called fMRI) unsafe.
Age Range
18-21
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
Yes
What is Involved?
Description
The purpose of this study is to evaluate how certain childhood experiences influences brain function and responses to nicotine exposure in a group of nonsmoking young adults. This study will help us to learn more about why some childhood experiences (adverse childhood experiences, or ACEs) contribute to increased risk for smoking and other substance use.
Locations
Duke University Hospital
Other
Visit Timing
Weekdays
Compensation
Yes
Spanish Materials Available
No
Study Details
Full Title
Neurobehavioral mechanisms linking childhood adversity to increased risk for smoking
Study Website
Principal Investigator
Maggie
Sweitzer
Protocol Number
PRO00110997
NCT ID
NCT05665465
Phase
0
Enrollment Status
Open to Enrollment