CROWN Study (Breast Cancer)

Purpose of this Study

We are doing this study to better understand how breast cancer treatment can affect the heart. In particular, we want to know if treatment with near complete estrogen deprivation (NCED) therapy has an impact on heart function.

Who Can Participate?

Eligibility

Women ages 55 or younger who:<ul>
<li>Are premenopausal when they receive their breast cancer diagnosis</li>
<li>Have Stage 1-to-3 breast cancer</li>
<li>Have recently started or plan to start breast cancer treatment therapy</li></ul>
For more information about who can be in this study, please contact the study team at <a href="BreastCl@dm.duke.edu">BreastCl@dm.duke.edu.</a>

Age Range

18-55

Sex/Genders

Female (cisgender)
Looking for Healthy Participants
No

What is Involved?

If you choose to join this study, you will:<ul>
<li>Have 3 heart stress tests over the course of 2 years</li>
<li>Have a cardiac MRI at the beginning of the study, at the 1 year mark, and at the end of the study</li>
<li>Get a CT scan at the beginning of the study and 2 years later at the end</li>
<li>Have an EKG/ECG (measures the electrical signal from the heart) 3 times</li>
<li>Have up to 6 blood draws throughout the study</li></ul>

Locations

Duke University Hospital
Duke Raleigh Hospital
Other

Visit Timing

Weekdays

Compensation

Yes

Spanish Materials Available

Yes

Study Details

Full Title

The Cardiac Outcomes with Near-complete Estrogen Deprivation (CROWN) Study

Principal Investigator

Alexandra
Thomas

Protocol Number

PRO00110774

NCT ID

NCT05309655

Phase

N/A

Enrollment Status

Open to Enrollment