Purpose of this Study
We are doing this study to understand how environmental exposures may be involved in lung function. We want to find out how immune cells in the lungs are affected by irritants that are present in the environment.
Who Can Participate?
Eligibility
Adults ages 18-55 who:
- Are in good general health; OR
- Have a history of COVID-19 that resulted in mild symptoms and no evidence of a lower respiratory tract infection and no need for supplemental oxygen; OR
- Have a history of COVID-19 that resulted in a documented lower respiratory tract infection at least 6 months ago and have since recovered and are breathing normally
Age Range
18-55
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
Yes
What is Involved?
Description
If you choose to join this study, you will:
- Have a 1-day screening visit that includes a blood draw and breathing tests
- Have a 2-day series of testing that includes a blood draw and a brief breathing test before and after inhaling air that contains either filtered air or ozone
- Have a bronchoscopy
- Have a second 2-day series of testing 18-20 days after the first series (whatever type of air you did not get the first time will be delivered to you this time)
Locations
Duke University Hospital
Other
Visit Timing
Weekdays
Compensation
Yes
Spanish Materials Available
No
Study Details
Full Title
Macrophage Regulation of Ozone-Induced Lung Inflammation (MOLI Study)
Principal Investigator
Robert
Tighe
Protocol Number
PRO00110603
NCT ID
NCT05773001
Phase
N/A
Enrollment Status
Open to Enrollment