Purpose of this Study
We are doing this study to evaluate whether exercise training following allogeneic stem cell transplant can improve physical function, cognitive function, mental health, social support, and quality of life.
Who Can Participate?
Eligibility
Adults aged 18-80 who:<ul>
<li>Are 60-120 days post-allogeneic stem cell transplant at Duke</li>
<li>Are able to safely take part in an exercise program (you will do CPET testing to be cleared to participate)</li></ul>
The caregivers of these patients may also participate.
For more information about who can join this study, please contact the study team at <a href= "mailto: lauren.hill@duke.edu">lauren.hill@duke.edu</a> or 919-668-2369.
<li>Are 60-120 days post-allogeneic stem cell transplant at Duke</li>
<li>Are able to safely take part in an exercise program (you will do CPET testing to be cleared to participate)</li></ul>
The caregivers of these patients may also participate.
For more information about who can join this study, please contact the study team at <a href= "mailto: lauren.hill@duke.edu">lauren.hill@duke.edu</a> or 919-668-2369.
What is Involved?
If you choose to join the study, you will:<ul>
<li>Be assigned to an exercise program that consists of three 30-minute high-intensity interval training (HIIT) sessions and two resistance training sessions per week for 12 weeks.
<li>Use an Apple Watch and iPhone to track your activity and complete daily entries in an app
<li>Fill out questionnaires</li>
<li>Do assessments to measure your physical function</li>
<li>Have Cardiopulmonary Exercise Testing (CPET) done</li>
<li>Have complete body composition testing done</li>
<li>Have your muscles scanned with a handheld ultrasound device</li>
<li>Give stool samples</li>
<li>Have your skin swabbed</li>
<li>Have blood draws</li>
<li>Monitor your vital signs at home with a scale and blood pressure cuff</li></ul>
If your caregiver chooses to join the study, they will:<ul>
<li>Be assigned to an exercise program that consists of three 30-minute high-intensity interval training (HIIT) sessions and two resistance training sessions per week for 12 weeks</li>
<li>Fill out questionnaires</li>
<li>Do assessments to measure their physical function</li>
<li>Have Cardiopulmonary Exercise Testing (CPET) done</li>
<li>Give stool samples</li>
<li>Have their skin swabbed</li></ul>
<li>Be assigned to an exercise program that consists of three 30-minute high-intensity interval training (HIIT) sessions and two resistance training sessions per week for 12 weeks.
<li>Use an Apple Watch and iPhone to track your activity and complete daily entries in an app
<li>Fill out questionnaires</li>
<li>Do assessments to measure your physical function</li>
<li>Have Cardiopulmonary Exercise Testing (CPET) done</li>
<li>Have complete body composition testing done</li>
<li>Have your muscles scanned with a handheld ultrasound device</li>
<li>Give stool samples</li>
<li>Have your skin swabbed</li>
<li>Have blood draws</li>
<li>Monitor your vital signs at home with a scale and blood pressure cuff</li></ul>
If your caregiver chooses to join the study, they will:<ul>
<li>Be assigned to an exercise program that consists of three 30-minute high-intensity interval training (HIIT) sessions and two resistance training sessions per week for 12 weeks</li>
<li>Fill out questionnaires</li>
<li>Do assessments to measure their physical function</li>
<li>Have Cardiopulmonary Exercise Testing (CPET) done</li>
<li>Give stool samples</li>
<li>Have their skin swabbed</li></ul>
Study Details
Full Title
The effect of high-intensity interval training (HIIT) and resistance training on function, health, and quality of life outcomes following hematopoietic stem cell transplant
Principal Investigator
Chenyu
Lin
Protocol Number
PRO00110028
NCT ID
NCT05238376
Enrollment Status
Open to Enrollment