Purpose of this Study
We are doing this study to find out if a new method to train the breathing muscles is effective. We want to know if this training can improve how well people can move and exercise underwater while connected to oxygen (i.e., while diving).
Specifically, we want to test whether or not these methods can increase personal endurance and reduce excessive rise in blood carbon dioxide during underwater exercise in divers. We will also look at how oxygen and carbon dioxide enters and leaves blood cells and how it affects exercise capacity.
Specifically, we want to test whether or not these methods can increase personal endurance and reduce excessive rise in blood carbon dioxide during underwater exercise in divers. We will also look at how oxygen and carbon dioxide enters and leaves blood cells and how it affects exercise capacity.
Who Can Participate?
Eligibility
People ages 18-45 who:
- Are in good general health
- Do not smoke
- Do not have heart or lung disease
- Are not pregnant
For more information please contact the study team at DIAPHRAGMstudy@duke.edu.
- Are in good general health
- Do not smoke
- Do not have heart or lung disease
- Are not pregnant
For more information please contact the study team at DIAPHRAGMstudy@duke.edu.
Age Range
18-45
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
Yes
What is Involved?
In this study, we will test the effect of daily breathing muscle training on breathing muscle performance and underwater exercise endurance during a dive to 55 feet of sea water. Breathing muscle training will require 30 minutes every day, 5 days per week for 4 weeks. During this training, each participant will breathe either air or a very low dose of carbon monoxide, which is safe and believed to improve muscle function.
Before and after the endurance test (which usually takes around 2 hours), there will be some tests to measure breathing capabilities. During the endurance test blood samples will be obtained.
Study participants are paid for their time.
Before and after the endurance test (which usually takes around 2 hours), there will be some tests to measure breathing capabilities. During the endurance test blood samples will be obtained.
Study participants are paid for their time.
Locations
Duke University Hospital
Visit Timing
Weekdays
Compensation
Yes
Spanish Materials Available
No
Study Details
Full Title
Diaphragm Function, Chemosensitivity and Endurance in Exercising Divers
Study Website
Principal Investigator
Richard
Moon
Protocol Number
PRO00107090
NCT ID
NCT04679402
Phase
I/II
Enrollment Status
OPEN TO ACCRUAL