Purpose of this Study
We are doing this study to find out if the study intervention (additional delayed MRI sequences) can tell the difference between radiation damage and tumor recurrence.
Who Can Participate?
Eligibility
-Adults, 18 or older
-Have any metastatic solid tumor except small cell lung cancer or myeloma
-Have at least 1 brain metastasis previously treated with Stereotactic Radiosurgery (SRS) with progression at the treated site(s)
-Able to have Laser Interstitial Thermal Therapy (LITT)
*If you had whole brain radiotherapy before, that is allowed but not required
For more information about who can be in this study, please contact the study team.
-Have any metastatic solid tumor except small cell lung cancer or myeloma
-Have at least 1 brain metastasis previously treated with Stereotactic Radiosurgery (SRS) with progression at the treated site(s)
-Able to have Laser Interstitial Thermal Therapy (LITT)
*If you had whole brain radiotherapy before, that is allowed but not required
For more information about who can be in this study, please contact the study team.
Age Range
18-100
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No
What is Involved?
If you choose to join this study, you will:
-Have more images taken about 1 hour after your regular MRI
-Let the study team to collect information from your medical record for 2 years
-Have more images taken about 1 hour after your regular MRI
-Let the study team to collect information from your medical record for 2 years
Locations
Duke University Hospital
Visit Timing
Weekdays
Compensation
No
Spanish Materials Available
No
Study Details
Full Title
Diagnostic Accuracy of Delayed MRI Contrast Enhancement Characteristics and Radiation Necrosis Following Stereotactic Radiosurgery (SRS) for Brain Metastases
Principal Investigator
Scott
Floyd
Protocol Number
PRO00103163
NCT ID
NCT04246879
Phase
Pilot
Enrollment Status
OPEN TO ACCRUAL