NDPH biomarker study (New Daily Persistent Headache)

Purpose of this Study

We are doing this study to learn more about the rare diagnosis of New Daily Persistent Headache (NDPH). We want to get more information about why some children and young people develop this condition and how it is different from traditional headaches, like migraines. This knowledge can help us to begin developing possible treatments for NDPH.

Who Can Participate?

Eligibility

Adolescents ages 12-18 who:
  • Are diagnosed with or suspected to have NDPH
  • Have no history of Raynaud's syndrome
  • Have no history of concussion or neurosurgery
Healthy adolescents with no medical issues or adolescents with a history of normal migraine headaches can also join the study as control participants and give a blood sample. For more information, please contact the study team at brittany.nave@duke.edu.

Age Range

12-18

Sex/Genders

Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
Yes

What is Involved?

Description

If you choose to have your child join this study, they will:
  • Visit our clinic 2 times
  • Have an exam
  • Have blood draws
  • Answer questionnaires
  • Keep a diary of their headache symptoms for 4 months
The visits to our clinic for this study will be about 4 months apart. Their study participation will end after the second visit. The study doctor might suggest some headache remedies to try during their time in the study.

Locations

Duke University Hospital

Visit Timing

Weekdays

Compensation

No

Spanish Materials Available

No

Study Details

Full Title

New Daily Persistent Headache (NDPH): Biomarker study and therapy in children and adolescents.

Principal Investigator

Klaus-Georg
Werner

Protocol Number

PRO00113907

NCT ID

NCT06018025

Phase

N/A

Enrollment Status

Open to Enrollment
ClinicalTrials.gov