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403 clinical trials found.
Brain, Spinal Cord and Nerves

We are doing this study to learn more about the connection between the brain and leg muscles in people who have chronic stroke. We want to understand how this connection affects the walking abilities of chronic stroke patients so we can provide better help to stroke patients who need to improve their motor function.

Compensation: Yes
Ages: 21-85
Non-Oncology
Duke University Hospital
Vaccine

We are doing this study to see if there is any difference in the safety and effectiveness of flu and COVID-19 vaccines if they are given at the same time or 1-2 weeks apart.

Compensation: Yes
Ages: 18-110
Non-Oncology
Other
Blood Disorders

We are doing this study to find out if a new type of assessment works well for middle-aged and older adults with sickle cell disease (SCD). We want to see if this assessment is useful in detecting changes in health. We hope the assessment can provide useful information to help improve the quality of life for adults with sickle cell disease.

Compensation: Yes
Ages: 40-110
Non-Oncology
Duke University Hospital
Breast Cancer

We are doing this study to find out if an experimental drug called lasofoxifene (the study drug) is a safe and effective option for breast cancer. We want to see if the study drug combined with another drug called abemaciclib has better results than treatment with abemaciclib plus fulvestrant.

Compensation: Yes
Ages: 18-89
Oncology
Duke University Hospital, Duke Raleigh Hospital
Pregnancy Concerns

We are doing this study to learn more about how different factors in pregnancy lead to healthy babies. Specifically, whether factors related to father's health affect the placenta and baby, what part of placental and fetal genes are related to placenta health and baby growth, and to find out the best time to deliver when the mother has gestational diabetes.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital, Duke Regional Hospital, Other
Brain and Spine Metastasis

We are doing this study to find out the highest dose of a drug called olaparib that is safe to give at the same time as stereotactic radiosurgery (SRS). We also want to see if we can lessen the chance of having your cancer return by following the olaparib + SRS treatment with a combination of chemotherapy and a drug called durvalumab.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Surgery and Rehabilitation

We are doing this study to find out if the Nectero EAST System® (the study procedure) is a safe and effective option for treating abdominal aortic aneurysms that are small to medium in size.

Compensation: No
Ages: 21-85
Non-Oncology
Duke University Hospital
Bones, Joints and Muscles

We are doing this study to figure out the best approaches for treating knee injuries that involve more than one ligament. There are 2 primary goals of this study. In Aim 1 of the study, we want to find out if it is better to have surgery shortly after MLKI or if it is better to delay surgery. In Aim 2 of the study, we want to find out if it is better to start physical rehabilitation shortly after surgery or if it is better to delay rehabilitation for a few weeks.

Compensation: Yes
Non-Oncology
Duke University Hospital, Other