Clinical Trials Directory

168 clinical trials found.
Skin Cancer - Non Melanoma Skin Disorders

We are doing this study to find out if an experimental drug called patidegib (the study drug) is a safe and effective option for people diagnosed with Gorlin syndrome. We want to know if it can help lower the number of basal cell carcinomas on the face.

Compensation: Yes
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called SLN124 (the study drug). We want to know how well this study drug works in people with PV.

Compensation: No
Oncology
Breast Cancer

We are doing this study to find out if an experimental drug called lasofoxifene (the study drug) is a safe and effective option for breast cancer. We want to see if the study drug combined with another drug called abemaciclib has better results than treatment with abemaciclib plus fulvestrant.

Compensation: Yes
Ages: 18-89
Oncology
Duke University Hospital, Duke Raleigh Hospital
Brain and Spine Metastasis

We are doing this study to find out the highest dose of a drug called olaparib that is safe to give at
the same time as stereotactic radiosurgery (SRS). We also want to see if we can lessen the chance of having your cancer return by following the olaparib + SRS treatment with a combination of chemotherapy and a drug called durvalumab.

Compensation: No
Oncology
Brain and Spine Metastasis

We are doing this study to find out if an investigational drug called XL092 (the study drug) is a safe and effective option on its own or in combination with other anticancer drugs.

Compensation: No
Oncology
Brain and Spine Metastasis

We are doing this study to see if the study drug, QTX3034, either with or without cetuximab, is safe and effective for treating KRAS G12D mutated cancer. We are also trying to find the best dose of QTX3034 to use.

Compensation: No
Oncology
Brain and Spine Metastasis

We are doing this study to find out if an experimental drug called RO7589831 (the study drug) is a safe and effective option for cancers with solid tumors. We also want to find out what the best dose of the study drug is in this study.

Compensation: No
Oncology
Hematologic Malignancies and Cellular Therapy

We are doing this study to figure out how well an investigational drug called CGT9486 (the study drug - also known as bezuclastinib) works in people who are diagnosed with a type of Nonadvanced Systemic Mastocytosis (NonAdvSM). These types are either Indolent Systemic Mastocytosis (ISM) or Smoldering Systemic Mastocytosis (SSM).

Compensation: No
Oncology