Purpose of this Study
This study will last about 8 weeks, but the time can change based on your schedule. People in the study will smoke special cigarettes instead of their usual ones. These cigarettes will have either a normal amount of nicotine or a very low amount. Which type you get will be random, like flipping a coin. Participants will have several visits: a remote screening (2 hours), an in-person screening (1 hour), two sessions after not smoking for 24 hours (90 minutes each), and five weekly visits (60–90 minutes each). There is also an optional part with four visits over 12 weeks to help quit smoking.
Who Can Participate?
Eligibility
To join this study, you must be 21 years or older and have chronic pain, like pain in your lower back or arthritis. You must have been taking buprenorphine from a doctor for at least 30 days. You also need to smoke at least 10 cigarettes every day, but you cannot regularly use other tobacco products like vapes or chewing tobacco. You cannot join if you are pregnant, trying to get pregnant, or breastfeeding.
Age Range
21-110
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No
What is Involved?
Description
The study wants to see what happens when people with chronic pain who smoke every day switch to cigarettes with very little nicotine compared to regular cigarettes. The researchers will look at how this change affects cravings, withdrawal symptoms, and pain. The people in the study are also getting a treatment called buprenorphine in a doctor's office.
Locations
Other
Visit Timing
Weekdays
Compensation
Yes
Spanish Materials Available
No
Study Details
Full Title
Targeting Reinforcement Mechanisms for Smoking Cessation Using Very Low Nicotine Content Cigarettes in Individuals with Opioid Use Disorder and Chronic Pain
Study Website
Principal Investigator
Maggie
Sweitzer
Protocol Number
PRO00116478
NCT ID
NCT06747871
Phase
N/A
Enrollment Status
Open to Enrollment