Purpose of this Study
We are doing this study to find out how safe and effective an experimental drug called MVR-C5252 (the study drug) is for people with advanced brain cancer.
Who Can Participate?
Eligibility
Adults ages 18+ who are diagnosed with recurrent high-grade glioma.
For more information about this study, please call 919-684-5301.
Age Range
18-110
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No
What is Involved?
Description
If you join the study, you will:
- Have a physical and neurological exam and other tests
- Have magnetic resonance imaging (MRI) of the brain
- Have blood draws
- Have brain tumor biopsy and testing of tumor sample
- Have a catheter (small flexible tube) placed in and around the tumor with the other end of the catheter extending slightly outside of the head
- Get the study drug infused through an external pump and the implanted catheter
Locations
Duke University Hospital
Visit Timing
Weekdays
Compensation
No
Spanish Materials Available
No
Study Details
Full Title
The PuMP Trial: A Multistage Phase 1 Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252 in Patients with Recurrent High-Grade Glioma
Principal Investigator
Mustafa
Khasraw
Protocol Number
PRO00112883
NCT ID
NCT06126744
Phase
I
Enrollment Status
Open to Enrollment