Purpose of this Study
We are doing this study to learn more about why the right side of the heart doesn't work well in certain heart conditions. We're using heart tissue samples from people with specific heart problems to help us make these important discoveries.
Who Can Participate?
Eligibility
Adults ages 18+ who are scheduled to receive either of the following surgeries:
- LVAD implant; OR
- LVAD explant due to heart transplant
Age Range
18-110
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No
What is Involved?
Description
LVAD Implant Patients
If you choose to join this study and are eligible because you have a scheduled surgery to get a left ventricular assist device (LVAD), your surgeon will use a precise biopsy needle to obtain two tissue samples from the right ventricular heart muscle, and each tissue sample will measure around 2 mm in size.
Heart Transplant PatientsPatients
If you choose to join this study and are eligible because you have a scheduled surgery to get a heart transplant, we will get your permission to store some of your heart or vascular tissue indefinitely for research. This tissue would normally be discarded (thrown away) after being sent to pathology for examination.
For all all participants in the study, the following will occur:
- We will collect information from your medical records.
- We will draw small blood samples from for research purposes before and after surgery.
Locations
Duke University Hospital
Visit Timing
Weekdays
Weekends
Evenings
Compensation
No
Spanish Materials Available
No
Study Details
Full Title
Linking Phenotyping to Molecular Signatures in Right Ventricular Dysfunction
Principal Investigator
Mohammed
Aslam
Protocol Number
PRO00116670
Phase
Pilot
Enrollment Status
Pending Open to Enrollment