Purpose of this Study
We are doing this study to find out how changes in air pressure can affect people's exercise capacity. We want to compare how these pressure changes affect the abilities of healthy volunteers and compare their changes to those of people who are diagnosed with HFpEF (heart failure with a preserved ejection fraction, a congestive heart disease).
Who Can Participate?
Eligibility
Adults ages 30+ who:
- Are in general good health (no heart, lung, or neurological conditions)
- Are able to pedal a stationary bike
Age Range
30-110
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
Yes
What is Involved?
Description
If you choose to join the study, you will come to our clinic for 1 visit that lasts about 3 hours.
During this visit, you will:
- Answer some questionnaires
- Have blood draws and give urine samples
- Have a small amount of radioactive medication administered to you
- Wear several noninvasive measurement devices
- Exercise on a stationary bicycle while exposed to different air pressures
Locations
Other
Visit Timing
Weekdays
Compensation
Yes
Spanish Materials Available
No
Study Details
Full Title
Blood volume redistribution in HFpEF through LBNP/LBPP and the impact on exercise performance
Study Website
Principal Investigator
David
MacLeod
Protocol Number
PRO00112081
NCT ID
NCT05764564
Phase
N/A
Enrollment Status
Open to Enrollment